Infant Group B Streptococcal Disease Incidence and Serotypes Worldwide: Systematic Review and Meta-analyses.
Infant Group B Streptococcal Disease Incidence and Serotypes Worldwide: Systematic Review and Meta-analyses.
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DOI：
10.1093/cid/cix656
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发表时间：
2017-11-06
期刊：
影响因子：
--
通讯作者：
Infant GBS Disease Investigator Group
中科院分区：
文献类型：
--
作者：
Madrid L;Seale AC;Kohli-Lynch M;Edmond KM;Lawn JE;Heath PT;Madhi SA;Baker CJ;Bartlett L;Cutland C;Gravett MG;Ip M;Le Doare K;Rubens CE;Saha SK;Sobanjo-Ter Meulen A;Vekemans J;Schrag S;Infant GBS Disease Investigator Group
尽管产时抗生素预防 (IAP) 导致 B 族链球菌 (GBS) 数量有所下降，但 B 族链球菌 (GBS) 仍然是高收入环境中新生儿败血症的主要原因。最近的证据表明非洲的发病率较高，而那里的 IAP 很少见。我们调查了婴儿侵袭性 GBS 疾病的全球发病率和相关血清型，更新了之前的估计。我们进行了系统文献综述（PubMed/Medline、Embase、拉丁美洲和加勒比健康科学文献 [LILACS]、世界卫生组织图书馆信息系统 [WHOLIS] 和 Scopus），并寻找有关 0-89 天婴儿侵袭性 GBS 疾病的未发表数据。我们对发病率、病死风险 (CFR) 和血清型流行率进行了随机效应荟萃分析。我们确定了 135 项研究，其中包含发病率 (n = 90)、病死率 (n = 64) 或血清型 (n = 45) 的数据。婴儿侵袭性 GBS 疾病的汇总发病率为每 1000 名活产 0.49 例（95% 置信区间 [CI]，0.43–0.56），非洲最高（1.12），亚洲最低（0.30）。早发型发病率为 0.41 (95% CI, .36–.47)；晚发型发病率为 0.26 (95% CI, .21–.30)。 CFR 为 8.4%（95% CI，6.6%–10.2%）。血清型 III (61.5%) 占主导地位，其中 97% 的病例由血清型 Ia、Ib、II、III 和 V 引起。在一些地区，特别是非洲，婴儿 GBS 疾病的发病率仍然很高。由于病例确定以及标本采集和处理方面的限制，我们可能低估了某些情况下的发病率。亚洲的负担需要进一步调查。
Group B Streptococcus (GBS) remains a leading cause of neonatal sepsis in high-income contexts, despite declines due to intrapartum antibiotic prophylaxis (IAP). Recent evidence suggests higher incidence in Africa, where IAP is rare. We investigated the global incidence of infant invasive GBS disease and the associated serotypes, updating previous estimates. We conducted systematic literature reviews (PubMed/Medline, Embase, Latin American and Caribbean Health Sciences Literature [LILACS], World Health Organization Library Information System [WHOLIS], and Scopus) and sought unpublished data regarding invasive GBS disease in infants aged 0–89 days. We conducted random-effects meta-analyses of incidence, case fatality risk (CFR), and serotype prevalence. We identified 135 studies with data on incidence (n = 90), CFR (n = 64), or serotype (n = 45). The pooled incidence of invasive GBS disease in infants was 0.49 per 1000 live births (95% confidence interval [CI], .43–.56), and was highest in Africa (1.12) and lowest in Asia (0.30). Early-onset disease incidence was 0.41 (95% CI, .36–.47); late-onset disease incidence was 0.26 (95% CI, .21–.30). CFR was 8.4% (95% CI, 6.6%–10.2%). Serotype III (61.5%) dominated, with 97% of cases caused by serotypes Ia, Ib, II, III, and V. The incidence of infant GBS disease remains high in some regions, particularly Africa. We likely underestimated incidence in some contexts, due to limitations in case ascertainment and specimen collection and processing. Burden in Asia requires further investigation.
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影响因子：
5.2
作者：
Campisi E;Rosini R;Ji W;Guidotti S;Rojas-López M;Geng G;Deng Q;Zhong H;Wang W;Liu H;Nan C;Margarit I;Rinaudo CD
通讯作者：
Rinaudo CD
影响因子：
2
作者：
Abdelmaaboud, Mohamed;Mohammed, Abdelbaset Fakhry
通讯作者：
Mohammed, Abdelbaset Fakhry
DOI：
10.1093/cid/cix661
发表时间：
2017-11-06
期刊：
Clinical infectious diseases : an official publication of the Infectious Diseases Society of America
影响因子：
--
作者：
Bianchi-Jassir F;Seale AC;Kohli-Lynch M;Lawn JE;Baker CJ;Bartlett L;Cutland C;Gravett MG;Heath PT;Ip M;Le Doare K;Madhi SA;Saha SK;Schrag S;Sobanjo-Ter Meulen A;Vekemans J;Rubens CE
通讯作者：
Rubens CE
影响因子：
8
作者：
Berardi, Alberto;Rossi, Cecilia;Ferrari, Fabrizio
通讯作者：
Ferrari, Fabrizio
影响因子：
--
作者：
Bell, Y;Barton, M;Trotman, H
通讯作者：
Trotman, H