Phase I and II enzyme polymorphisms as risk factors for Barrett's esophagus and esophageal adenocarcinoma: a systematic review and meta-analysis.
Phase I and II enzyme polymorphisms as risk factors for Barrett's esophagus and esophageal adenocarcinoma: a systematic review and meta-analysis.
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DOI：
10.1111/j.1442-2050.2009.00947.x
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发表时间：
2009
期刊：
影响因子：
--
通讯作者：
El-Serag HB
中科院分区：
文献类型：
--
作者：
Bull LM;White DL;Bray M;Nurgalieva Z;El-Serag HB
尽管一些研究已经研究了I/II期酶多态性与食管腺癌（EAC）和/或巴雷特食管（BE）之间的关系，但它们的总体结果仍不清楚。我们进行了系统回顾和荟萃分析，以确定I/II期多态性是否是BE或EAC的独立危险因素。我们在多个数据库中使用关键字搜索来识别2007年10月1日之前发表的研究。对≥3项研究中检测的单核苷酸多态性（snp）进行meta分析，以获得综合效应估计。荟萃分析显示，GSTP1 Val105的次要等位基因具有适度的额外风险（优势比[OR]BE = 1.50, 95%可信区间[CI] 1.16-1.95; OREAC = 1.20, 95% CI 0.94-1.54）。GSTM1无效（ORBE = 0.77, 95% CI: 0.56-1.08; OREAC = 1.08, 95% CI: 0.79-1.48）、GSTT1无效（ORBE = 1.35, 95% CI: 0.91-2.01; OREAC = 0.84, 95% CI: 0.48-1.49）或CYP1A Val462 （OREAC = 0.89, 95% CI: 0.40-1.97）均未观察到额外的风险。没有足够的数据对剩余的snp进行meta分析。我们的综述确定GSTP1Ile105Val可能是白种人男性BE和EAC的危险因素。其他I/II期多态性没有观察到额外的风险，有足够的数据进行meta分析。需要进一步的研究来确定GSTP1是否在女性或非白种人中传递了额外的风险，并评估其他I/II期多态性。
Although several studies have examined the association between phase I/II enzyme polymorphisms and esophageal adenocarcinoma (EAC) and/or Barrett’s esophagus (BE), their overall findings remain unclear. We performed a systematic review and meta-analysis to determine whether phase I/II polymorphisms are independent risk factors for either BE or EAC. We employed keyword searches in multiple databases to identify studies published before October 1, 2007. Single-nucleotide polymorphisms (SNPs) examined in ≥3 studies were meta-analyzed to obtain a pooled estimate of effect. Meta-analysis suggested the minor allele for GSTP1 Val105 conveys modest excess risk (odds ratio [OR]BE = 1.50, 95% confidence interval [CI] 1.16–1.95; OREAC = 1.20, 95% CI 0.94–1.54). No excess risk was observed with GSTM1 null (ORBE = 0.77, 95% CI: 0.56–1.08; OREAC = 1.08, 95% CI: 0.79–1.48), GSTT1 null (ORBE = 1.35, 95% CI: 0.91–2.01; OREAC = 0.84, 95% CI: 0.48–1.49), or CYP1A Val462 (OREAC = 0.89, 95% CI: 0.40–1.97). Insufficient data existed to meta-analyze remaining SNPs. Our review identified GSTP1Ile105Val as a possible risk factor for BE and EAC in Caucasian males. No excess risk was observed for other phase I/II polymorphisms with sufficient data to meta-analyze. Additional studies are needed to determine if GSTP1 conveys excess risk in females or non-Caucasians and to evaluate other phase I/II polymorphisms.
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影响因子：
168.9
作者：
Hattersley, AT;McCarthy, MI
通讯作者：
McCarthy, MI
影响因子：
3.5
作者：
HASSETT, C;AICHER, L;OMIECINSKI, CJ
通讯作者：
OMIECINSKI, CJ
DOI：
10.1016/0197-2456(86)90046-2
发表时间：
1986-09-01
期刊：
CONTROLLED CLINICAL TRIALS
影响因子：
--
作者：
DERSIMONIAN, R;LAIRD, N
通讯作者：
LAIRD, N
影响因子：
4.7
作者：
Benhamou, S;Lee, WJ;Taioli, E
通讯作者：
Taioli, E
影响因子：
--
作者：
Casson, AG;Zheng, Z;McLaughlin, J
通讯作者：
McLaughlin, J