A coordination polymer for the site-specific integration of semiconducting sequences into DNA-based materials.
A coordination polymer for the site-specific integration of semiconducting sequences into DNA-based materials.
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DOI：
10.1038/s41467-017-00852-6
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发表时间：
2017-09-28
影响因子：
16.6
通讯作者：
Houlton A
中科院分区：
文献类型：
--
作者：
Al-Mahamad LLG;El-Zubir O;Smith DG;Horrocks BR;Houlton A
通过基于DNA的方法，自下而上的材料设计取得了重大进展。然而，将半导体特性，特别是长程电导，集成到DNA的基本拓扑基序中的常规集成仍然具有挑战性。在这里，我们用6-硫代鸟苷(6-TG-H)衍生的配位聚合物证明了这一点，6-TG-H是一种天然核苷的含硫类似物。与Au(I)离子的络合反应自发组装了发光的一维螺旋链，表征为{AuI(μ-6-Tg)}n，延伸了许多在结构上类似于天然μ的长度。独一无二的是，对于这样的材料，这种硫代金可以通过氧化掺杂转变为线状导电形式。我们还表明，这种自组装反应与6-TG修饰的DNA双链相容，并提供了一种直接的方法，通过这种方法将定点特定的半导体序列整合到DNA材料的框架中，以一种基本和技术上有用的方式转换它们的性质。将半导体特性集成到DNA的基本拓扑基序中仍然具有挑战性。在这里，作者展示了一种由6-硫代鸟苷衍生的配位聚合物，它与Au(I)离子络合形成一种线状材料，这种材料也可以将半导体序列集成到DNA材料的框架中。
Advances in bottom-up material design have been significantly progressed through DNA-based approaches. However, the routine integration of semiconducting properties, particularly long-range electrical conduction, into the basic topological motif of DNA remains challenging. Here, we demonstrate this with a coordination polymer derived from 6-thioguanosine (6-TG-H), a sulfur-containing analog of a natural nucleoside. The complexation reaction with Au(I) ions spontaneously assembles luminescent one-dimensional helical chains, characterized as {AuI(μ-6-TG)}n, extending many μm in length that are structurally analogous to natural DNA. Uniquely, for such a material, this gold-thiolate can be transformed into a wire-like conducting form by oxidative doping. We also show that this self-assembly reaction is compatible with a 6-TG-modified DNA duplex and provides a straightforward method by which to integrate semiconducting sequences, site-specifically, into the framework of DNA materials, transforming their properties in a fundamental and technologically useful manner. Integration of semiconducting properties into the basic topological motif of DNA remains challenging. Here, the authors show a coordination polymer derived from 6-thioguanosine that complexes with Au(I) ions to form a wire-like material that can also integrate semiconducting sequences into the framework of DNA materials.
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DOI：
10.1126/science.aag1789
发表时间：
2017-02-24
期刊：
Science (New York, N.Y.)
影响因子：
--
作者：
O'Brien E;Holt ME;Thompson MK;Salay LE;Ehlinger AC;Chazin WJ;Barton JK
通讯作者：
Barton JK
影响因子：
15
作者：
Kim, Youngeun;Macfarlane, Robert J.;Mirkin, Chad A.
通讯作者：
Mirkin, Chad A.
影响因子：
21.8
作者：
Johannsen, Silke;Megger, Nicole;Mueller, Jens
通讯作者：
Mueller, Jens
影响因子：
15
作者：
Atwell, S;Meggers, E;Schultz, PG
通讯作者：
Schultz, PG
DOI：
10.1073/pnas.122610899
发表时间：
2002-06-25
影响因子：
11.1
作者：
Gómez-Navarro, C;Moreno-Herrero, F;Baró, AM
通讯作者：
Baró, AM