Silent trace eliminates differential eyeblink learning in abstinent alcoholics.
Silent trace eliminates differential eyeblink learning in abstinent alcoholics.
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DOI:
10.3390/ijerph6072007
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发表时间:
2009-07
影响因子:
--
通讯作者:
McGlinchey RE
中科院分区:
文献类型:
--
作者:
Fortier CB;Maksimovskiy AL;Venne JR;LaFleche G;McGlinchey RE
Chronic alcoholism has profound effects on the brain, including volume reductions in regions critical for eyeblink classical conditioning (EBCC). The current study challenged abstinent alcoholics using delay (n = 20) and trace (n = 17) discrimination/reversal EBCC. Comparisons revealed a significant difference between delay and trace conditioning performance during reversal (t (35) = 2.08, p < 0.05). The difference between the two tasks for discrimination was not significant (p = 0.44). These data support the notion that alcoholics are increasingly impaired in the complex task of reversing a previously learned discrimination when a silent trace interval is introduced. Alcoholics’ impairment in flexibly altering learned associations may be central to their continued addiction.
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