Identifying regions in prefrontal cortex related to working memory improvement: A novel meta-analytic method using electric field modeling.
Identifying regions in prefrontal cortex related to working memory improvement: A novel meta-analytic method using electric field modeling.
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识别与工作记忆改善有关的前额叶皮层中的区域:一种使用电场建模的新型荟萃分析方法。
DOI:
10.1016/j.neubiorev.2021.08.017
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发表时间:
2021-11
影响因子:
8.2
通讯作者:
Opitz A
中科院分区:
文献类型:
--
作者:
Wischnewski M;Mantell KE;Opitz A
Altering cortical activity using transcranial direct current stimulation (tDCS) has been shown to improve working memory (WM) performance. Due to large inter-experimental variability in the tDCS montage configuration and strength of induced electric fields, results have been mixed. Here, we present a novel meta-analytic method relating behavioral effect sizes to electric field strength to identify brain regions underlying largest tDCS-induced WM improvement. Simulations on 69 studies targeting left prefrontal cortex showed that tDCS electric field strength in lower dorsolateral prefrontal cortex (Brodmann area 45/47) relates most strongly to improved WM performance. This region explained 7.8% of variance, equaling a medium effect. A similar region was identified when correlating WM performance and electric field strength of right prefrontal tDCS studies (n = 18). Maximum electric field strength of five previously used tDCS configurations were outside of this location. We thus propose a new tDCS montage which maximizes the tDCS electric field strength in that brain region. Our findings can benefit future tDCS studies that aim to affect WM function.
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