Cholinergic enhancement of visual attention and neural oscillations in the human brain.
Cholinergic enhancement of visual attention and neural oscillations in the human brain.
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DOI：
10.1016/j.cub.2012.01.022
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发表时间：
2012-03-06
期刊：
影响因子：
9.2
通讯作者：
Driver, Jon
中科院分区：
文献类型：
--
作者：
Bauer, Markus;Kluge, Christian;Bach, Dominik;Bradbury, David;Heinze, Hans Jochen;Dolan, Raymond J.;Driver, Jon
诸如视觉感知和选择性注意力的认知过程会引起脑振荡的特定模式。体外研究表明，胆碱能激动剂在切片制剂中诱导高频振荡。视觉注意力的胆碱能增强可能会通过视觉皮层中的伽马振荡作用，尽管低频α/beta调制也可能起关键作用。在人类中的空间视觉注意任务中。与药物诱导的性能相关的相关性。低频而不是高频。由Visual Cortex中的反馈途径生成。
►胆碱能激动剂在视觉注意任务中增强了人类的性能►枕骨α/β/β胆碱能控制下的γ振荡►α/β/β的注意力链胆碱能激动剂与行为的关注增强与行为的关系►解释的结果可能解释了dichotians canterions►可能解释了对解剖反馈连接的二分法的疾病。
Cognitive processes such as visual perception and selective attention induce specific patterns of brain oscillations. The neurochemical bases of these spectral changes in neural activity are largely unknown, but neuromodulators are thought to regulate processing. The cholinergic system is linked to attentional function in vivo, whereas separate in vitro studies show that cholinergic agonists induce high-frequency oscillations in slice preparations. This has led to theoretical proposals that cholinergic enhancement of visual attention might operate via gamma oscillations in visual cortex, although low-frequency alpha/beta modulation may also play a key role. Here we used MEG to record cortical oscillations in the context of administration of a cholinergic agonist (physostigmine) during a spatial visual attention task in humans. This cholinergic agonist enhanced spatial attention effects on low-frequency alpha/beta oscillations in visual cortex, an effect correlating with a drug-induced speeding of performance. By contrast, the cholinergic agonist did not alter high-frequency gamma oscillations in visual cortex. Thus, our findings show that cholinergic neuromodulation enhances attentional selection via an impact on oscillatory synchrony in visual cortex, for low rather than high frequencies. We discuss this dissociation between high- and low-frequency oscillations in relation to proposals that lower-frequency oscillations are generated by feedback pathways within visual cortex. ► Cholinergic agonist enhances human performance in a visuospatial attention task ► Occipital alpha/beta but not gamma oscillations under cholinergic control ► Alpha/beta attentional enhancement by cholinergic agonist relates to behavior ► Dichotomy of anatomical feedback versus feedforward connections may explain results
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影响因子：
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DOI：
10.1073/pnas.0809511105
发表时间：
2008-11-18
影响因子：
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