Arginase inhibition prevents the development of hypertension and improves insulin resistance in obese rats.
Arginase inhibition prevents the development of hypertension and improves insulin resistance in obese rats.
复制标题
DOI：
10.1007/s00726-018-2567-x
复制
发表时间：
2018-06
期刊：
影响因子：
3.5
通讯作者：
Durante W
中科院分区：
文献类型：
--
作者：
Peyton KJ;Liu XM;Shebib AR;Johnson FK;Johnson RA;Durante W
This study investigated the temporal activation of arginase in obese Zucker rats (ZR) and determined if arginase inhibition prevents the development of hypertension and improves insulin resistance in these animals. Arginase activity, plasma arginine and nitric oxide (NO) concentration, blood pressure, and insulin resistance were measured in lean and obese animals. There was a chronological increase in vascular and plasma arginase activity in obese ZR beginning at 8 weeks of age. The increase in arginase activity in obese animals was associated with a decrease in insulin sensitivity and circulating levels of arginine and NO. The rise in arginase activity also preceded the increase in blood pressure in obese ZR detected at 12 weeks of age. Chronic treatment of 8 week old obese animals with an arginase inhibitor or L-arginine for 4 weeks prevented the development of hypertension and improved plasma concentrations of arginine and NO. Arginase inhibition also improved insulin sensitivity in obese ZR while L-arginine supplementation had no effect. In conclusion, arginase inhibition prevents the development of hypertension and improves insulin sensitivity while L-arginine administration only mitigates hypertension in obese animals. Arginase represents a promising therapeutic target in ameliorating obesity-associated vascular and metabolic dysfunction.
登录
查看更多内容
影响因子：
20.1
作者：
Durante, W;Liao, L;Schafer, AI
通讯作者：
Schafer, AI
影响因子：
6.1
作者：
Barbosa, Thais de Castro;Poyares, Leonice Lourenco;Nunes, Maria Tereza
通讯作者：
Nunes, Maria Tereza
影响因子：
4
作者：
El-Bassossy, Hany M.;El-Fawal, Rania;Fahmy, Ahmed
通讯作者：
Fahmy, Ahmed
影响因子：
4.9
作者：
Gruber, H-J;Mayer, C.;Wilders-Truschnig, M.
通讯作者：
Wilders-Truschnig, M.
影响因子：
7.3
作者：
Huynh, N. N.;Harris, E. E.;Andrews, K. L.
通讯作者：
Andrews, K. L.