Obesity and nonalcoholic fatty liver disease: biochemical, metabolic, and clinical implications.
Obesity and nonalcoholic fatty liver disease: biochemical, metabolic, and clinical implications.
复制标题
DOI：
10.1002/hep.23280
复制
发表时间：
2010-02
期刊：
影响因子：
13.5
通讯作者：
Klein, Samuel
中科院分区：
文献类型：
--
作者：
Fabbrini, Elisa;Sullivan, Shelby;Klein, Samuel
肥胖与非酒精性脂肪性肝病（NAFLD）的风险增加有关。脂肪变性是NAFLD的标志性特征，当肝脏从血浆中摄取脂肪酸的速率和从头脂肪酸合成的速率大于脂肪酸氧化和输出的速率（作为VLDL中的甘油三酯）时发生。因此，过量的肝内甘油三酯代表代谢事件的复杂相互作用之间的不平衡。脂肪变性的存在与葡萄糖、脂肪酸和脂蛋白代谢的一系列不良改变有关。脂肪酸代谢异常，连同脂肪组织、肝脏和全身性炎症，可能是参与胰岛素抵抗、血脂异常和其他与NAFLD相关的心脏代谢风险因素发展的关键因素。然而，目前尚不清楚NAFLD是否导致代谢功能障碍或代谢功能障碍是否导致IHTG积累，或可能两者兼而有之。了解NAFLD的发病机制和病理生理学中涉及的确切因素将为肥胖的心脏代谢并发症的机制提供重要的见解。
Obesity is associated with an increased risk of nonalcoholic fatty liver disease (NAFLD). Steatosis, the hallmark feature of NAFLD, occurs when the rate of hepatic fatty acid uptake from plasma and de novo fatty acid synthesis is greater than the rate of fatty acid oxidation and export (as triglyceride within VLDL). Therefore, an excessive amount of intrahepatic triglyceride represents an imbalance between complex interactions of metabolic events. The presence of steatosis is associated with a constellation of adverse alterations in glucose, fatty acid and lipoprotein metabolism. It is likely that abnormalities in fatty acid metabolism, in conjunction with adipose tissue, hepatic, and systemic inflammation, are key factors involved in the development of insulin resistance, dyslipidemia and other cardiometabolic risk factors associated with NAFLD. However, it is not clear whether NAFLD causes metabolic dysfunction or whether metabolic dysfunction is responsible for IHTG accumulation, or possibly both. Understanding the precise factors involved in the pathogenesis and pathophysiology of NAFLD will provide important insights into the mechanisms responsible for the cardiometabolic complications of obesity.
登录
查看更多内容
影响因子：
158.5
作者：
Cuchel, Marina;Bloedon, LeAnne T.;Rader, Daniel J.
通讯作者：
Rader, Daniel J.
影响因子：
13.5
作者：
Browning, JD;Szczepaniak, LS;Hobbs, HH
通讯作者：
Hobbs, HH
DOI：
10.1152/ajpgi.00063.2005
发表时间：
2005-09-01
影响因子：
4.5
作者：
Grefhorst, A;Hoekstra, J;Kuipers, F
通讯作者：
Kuipers, F
影响因子：
2.9
作者：
Gholam, PM;Kotler, DP;Flancbaum, LJ
通讯作者：
Flancbaum, LJ
影响因子：
7.7
作者：
Gregor MF;Yang L;Fabbrini E;Mohammed BS;Eagon JC;Hotamisligil GS;Klein S
通讯作者：
Klein S