IFP35 as a promising biomarker and therapeutic target for the syndromes induced by SARS-CoV-2 or influenza virus.
IFP35 as a promising biomarker and therapeutic target for the syndromes induced by SARS-CoV-2 or influenza virus.
复制标题
IFP35 作为 SARS-CoV-2 或流感病毒引起的综合征的有前景的生物标志物和治疗靶点
DOI：
10.1016/j.celrep.2021.110126
复制
发表时间：
2021-12-21
期刊：
影响因子：
8.8
通讯作者：
Liang H
中科院分区：
文献类型：
--
作者：
Yu Y;Xu N;Cheng Q;Deng F;Liu M;Zhu A;Min YQ;Zhu D;Huang W;Feng X;Jing X;Chen Y;Yue D;Fan Y;Shu C;Guan Q;Yang Z;Zhao J;Song W;Guo D;Liu H;Zhao J;Lan P;Shi Z;Liu Y;Chen X;Liang H
以往的研究表明，严重急性呼吸综合征冠状病毒2(SARS-CoV-2)和流感病毒等病毒造成的高死亡率主要是细胞因子风暴的并发症造成的。因此，确定参与细胞因子风暴的关键因素至关重要。在此，我们证明了干扰素诱导蛋白35(IFP35)在SARS-CoV-2和流感病毒感染诱导的细胞因子风暴中起着重要作用。我们发现SARS-CoV-2患者的血清IFP35水平与综合征的严重程度相关。通过小鼠模型和细胞检测，我们发现SARS-CoV-2或流感病毒感染后，肺上皮细胞和巨噬细胞释放了IFP35。此外，我们还表明，给予IFP35的中和抗体可以显著减少肺损伤，从而降低暴露在病毒感染下的小鼠的死亡率。我们的研究结果表明，IFP35可作为病毒诱导综合征的生物标记物和治疗靶点。Yu等人。将IFP35确定为SARS-CoV-2或流感病毒诱导综合征的生物标记物和治疗靶点。针对IFP35的中和抗体显著减少了肺损伤和感染小鼠的死亡率。
Previous studies have shown that the high mortality caused by viruses such as severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) and influenza virus primarily results from complications of a cytokine storm. Therefore, it is critical to identify the key factors participating in the cytokine storm. Here we demonstrate that interferon-induced protein 35 (IFP35) plays an important role in the cytokine storm induced by SARS-CoV-2 and influenza virus infection. We find that the levels of serum IFP35 in individuals with SARS-CoV-2 correlates with severity of the syndrome. Using mouse model and cell assays, we show that IFP35 is released by lung epithelial cells and macrophages after SARS-CoV-2 or influenza virus infection. In addition, we show that administration of neutralizing antibodies against IFP35 considerably reduces lung injury and, thus, the mortality rate of mice exposed to viral infection. Our findings suggest that IFP35 serves as a biomarker and as a therapeutic target in virus-induced syndromes. Yu et al. identify IFP35 as a biomarker and as a therapeutic target in SARS-CoV-2- or influenza virus-induced syndromes. Neutralizing antibodies against IFP35 considerably reduces lung injury and the mortality of infected mice.
登录
查看更多内容
影响因子：
3.7
作者：
Oldstone MB;Teijaro JR;Walsh KB;Rosen H
通讯作者：
Rosen H
影响因子：
3.7
作者：
Gokhale Y;Mehta R;Kulkarni U;Karnik N;Gokhale S;Sundar U;Chavan S;Kor A;Thakur S;Trivedi T;Kumar N;Baveja S;Wadal A;Kolte S;Deolankar A;Pednekar S;Kalekar L;Padiyar R;Londhe C;Darole P;Pol S;Gokhe SB;Padwal N;Pandey D;Yadav D;Joshi A;Badgujar H;Trivedi M;Shah P;Bhavsar P
通讯作者：
Bhavsar P
DOI：
10.1126/science.abe8499
发表时间：
2020-12-18
期刊：
Science (New York, N.Y.)
影响因子：
--
作者：
Hou YJ;Chiba S;Halfmann P;Ehre C;Kuroda M;Dinnon KH 3rd;Leist SR;Schäfer A;Nakajima N;Takahashi K;Lee RE;Mascenik TM;Graham R;Edwards CE;Tse LV;Okuda K;Markmann AJ;Bartelt L;de Silva A;Margolis DM;Boucher RC;Randell SH;Suzuki T;Gralinski LE;Kawaoka Y;Baric RS
通讯作者：
Baric RS
影响因子：
5.2
作者：
Florescu DF;Kalil AC
通讯作者：
Kalil AC
影响因子：
--
作者：
Hornbeck, Peter V
通讯作者：
Hornbeck, Peter V