Metabolic Reprogramming of Cancer Cells during Tumor Progression and Metastasis.
Metabolic Reprogramming of Cancer Cells during Tumor Progression and Metastasis.
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肿瘤进展和转移过程中癌细胞的代谢重编程
DOI：
10.3390/metabo11010028
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发表时间：
2021-01-02
期刊：
影响因子：
4.1
通讯作者：
Morii E
中科院分区：
文献类型：
--
作者：
Ohshima K;Morii E
在肿瘤进展过程中，癌细胞面临着各种代谢挑战，包括在原发部位营养改变和缺氧的微环境中生长，需要锚定独立生长的血管内移入，以及在与原发部位环境不同的远端器官中定植。因此，癌细胞必须在癌症进展的每一步重新编程其代谢状态。代谢重编程现在被认为是癌细胞的标志，并支持癌症的生长。阐明癌细胞中代谢重编程的潜在机制可能有助于确定癌症靶点和治疗策略。本文综述了我们目前对癌症进展和转移过程中代谢重编程的理解，包括癌细胞对肿瘤微环境的适应，血管中不依赖锚定生长过程中对氧化应激的防御，以及转移过程中的代谢重编程。
Cancer cells face various metabolic challenges during tumor progression, including growth in the nutrient-altered and oxygen-deficient microenvironment of the primary site, intravasation into vessels where anchorage-independent growth is required, and colonization of distant organs where the environment is distinct from that of the primary site. Thus, cancer cells must reprogram their metabolic state in every step of cancer progression. Metabolic reprogramming is now recognized as a hallmark of cancer cells and supports cancer growth. Elucidating the underlying mechanisms of metabolic reprogramming in cancer cells may help identifying cancer targets and treatment strategies. This review summarizes our current understanding of metabolic reprogramming during cancer progression and metastasis, including cancer cell adaptation to the tumor microenvironment, defense against oxidative stress during anchorage-independent growth in vessels, and metabolic reprogramming during metastasis.
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影响因子：
82.9
作者：
Davidson SM;Jonas O;Keibler MA;Hou HW;Luengo A;Mayers JR;Wyckoff J;Del Rosario AM;Whitman M;Chin CR;Condon KJ;Lammers A;Kellersberger KA;Stall BK;Stephanopoulos G;Bar-Sagi D;Han J;Rabinowitz JD;Cima MJ;Langer R;Vander Heiden MG
通讯作者：
Vander Heiden MG
影响因子：
56.9
作者：
Chakraborty, Abhishek A.;Laukka, Tuomas;Kaelin, William G., Jr.
通讯作者：
Kaelin, William G., Jr.
影响因子：
64.8
作者：
Dey P;Baddour J;Muller F;Wu CC;Wang H;Liao WT;Lan Z;Chen A;Gutschner T;Kang Y;Fleming J;Satani N;Zhao D;Achreja A;Yang L;Lee J;Chang E;Genovese G;Viale A;Ying H;Draetta G;Maitra A;Wang YA;Nagrath D;DePinho RA
通讯作者：
DePinho RA
影响因子：
4
作者：
Balkwill, Frances R.;Capasso, Melania;Hagemann, Thorsten
通讯作者：
Hagemann, Thorsten
影响因子：
13.6
作者：
DeBerardinis RJ;Chandel NS
通讯作者：
Chandel NS