Promise of irisin to attenuate cognitive dysfunction in aging and Alzheimer's disease.
Promise of irisin to attenuate cognitive dysfunction in aging and Alzheimer's disease.
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DOI：
10.1016/j.arr.2022.101637
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发表时间：
2022-06
影响因子：
13.1
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中科院分区：
文献类型：
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作者：
策略熟练缓解认知障碍的老化和阿尔茨海默病（AD）有巨大的影响。定期体育锻炼（PE）可以预防年龄相关性痴呆，减缓AD进展。然而，这种生活方式的改变对于表现出与年龄相关的虚弱的个人来说可能是无法实现的。因此，能够模拟PE益处的药物或生物制剂受到了广泛关注。先前的研究表明，含纤连蛋白结构域III的5（FNDC5）是PE介导的认知功能改善的基础。最近的一项研究报告说，PE相关的认知益处在衰老和AD中是由Irisin介导的，Irisin是PE后释放到血液中的FNDC5的裂解形式。通过FNDC5的整体敲除删除鸢尾素，导致PE诱导的认知益处的丧失或诱导成人或老年模型中的记忆障碍，这一结论是显而易见的。此外，在AD模型中，外周给药的鸢尾素通过调节神经炎症来模拟PE的认知益处。这篇简短的综述讨论了鸢尾素模拟PE在年龄和AD相关痴呆症中的认知益处的前景。此外，关键问题，如血液传播的鸢尾素如何作用于神经细胞，脑源性神经营养因子在鸢尾素介导的认知益处中的作用，以及鸢尾素抑制衰老和AD中神经炎症级联反应的能力进行了讨论。
Strategies proficient for relieving cognitive impairments in aging and Alzheimer’s disease (AD) have an enormous impact. Regular physical exercise (PE) can prevent age-related dementia and slow down AD progression. However, such a lifestyle change is likely not achievable for individuals displaying age-related frailty. Hence, drugs or biologics that could simulate the benefits of PE have received much attention. Previous studies suggested that the fibronectin-domain III containing 5 (FNDC5) underlies the PE-mediated improved cognitive function. A recent study reports that PE-related cognitive benefits in aging and AD are mediated by irisin, the cleaved form of FNDC5 released into the blood after PE. Such a conclusion was apparent from the deletion of irisin through a global knockout of FNDC5, leading to the loss of PE-induced cognitive benefits or inducing memory impairments in adult or aged models. Furthermore, in AD models, peripherally administered irisin mimicked the cognitive benefits of PE by modulating neuroinflammation. This short review discusses the promise of irisin to simulate the cognitive benefits of PE in age- and AD-related dementia. In addition, critical issues such as how blood-borne irisin acts on neural cells, the role of the brain-derived neurotrophic factor in irisin-mediated cognitive benefits, and irisin’s ability to inhibit neuroinflammatory cascades in aging and AD are discussed.
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发表时间：
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影响因子：
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作者：
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DOI：
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发表时间：
2018-09-07
期刊：
Science (New York, N.Y.)
影响因子：
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