Alternative oxidase: a mitochondrial respiratory pathway to maintain metabolic and signaling homeostasis during abiotic and biotic stress in plants.
Alternative oxidase: a mitochondrial respiratory pathway to maintain metabolic and signaling homeostasis during abiotic and biotic stress in plants.
复制标题
替代氧化酶：在植物中非生物和生物胁迫期间保持代谢和信号稳态的线粒体呼吸道途径。
DOI：
10.3390/ijms14046805
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发表时间：
2013-03-26
影响因子：
5.6
通讯作者：
Vanlerberghe GC
中科院分区：
文献类型：
--
作者：
Vanlerberghe GC
交替氧化酶（AOX）是植物线粒体电子传递链上的一种非能量守恒末端氧化酶。虽然呼吸碳氧化途径、电子传递和ATP周转是紧密耦合的过程，但AOX提供了一种放松这种耦合的方法，从而为碳和能量代谢提供一定程度的代谢稳态。除了在初级代谢中的作用外，植物线粒体还充当“信号细胞器”，能够影响诸如核基因表达等过程。AOX活性可以控制潜在的线粒体信号分子，如超氧化物，一氧化氮和重要的氧化还原对的水平。以这种方式，AOX也为细胞器提供一定程度的信号稳态。有证据表明，AOX在代谢和信号稳态中的功能在应激期间特别重要。这些包括非生物胁迫，如低温、干旱和营养缺乏，以及生物胁迫，如细菌感染。这篇综述介绍了AOX呼吸的遗传和生化控制，并提供了AOX活性如何提供代谢和信号稳态的一般性例子。这篇评论还探讨了非生物和生物胁迫中AOX呼吸已被严格评估，并认为AOX在生长和胁迫耐受性的整体作用。
Alternative oxidase (AOX) is a non-energy conserving terminal oxidase in the plant mitochondrial electron transport chain. While respiratory carbon oxidation pathways, electron transport, and ATP turnover are tightly coupled processes, AOX provides a means to relax this coupling, thus providing a degree of metabolic homeostasis to carbon and energy metabolism. Beside their role in primary metabolism, plant mitochondria also act as “signaling organelles”, able to influence processes such as nuclear gene expression. AOX activity can control the level of potential mitochondrial signaling molecules such as superoxide, nitric oxide and important redox couples. In this way, AOX also provides a degree of signaling homeostasis to the organelle. Evidence suggests that AOX function in metabolic and signaling homeostasis is particularly important during stress. These include abiotic stresses such as low temperature, drought, and nutrient deficiency, as well as biotic stresses such as bacterial infection. This review provides an introduction to the genetic and biochemical control of AOX respiration, as well as providing generalized examples of how AOX activity can provide metabolic and signaling homeostasis. This review also examines abiotic and biotic stresses in which AOX respiration has been critically evaluated, and considers the overall role of AOX in growth and stress tolerance.
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影响因子：
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作者：
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通讯作者：
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