Role of free fatty acids in endothelial dysfunction.
Role of free fatty acids in endothelial dysfunction.
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DOI：
10.1186/s12929-017-0357-5
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发表时间：
2017-07-27
影响因子：
11
通讯作者：
Lai CWK
中科院分区：
文献类型：
--
作者：
Ghosh A;Gao L;Thakur A;Siu PM;Lai CWK
血浆游离脂肪酸水平在肥胖和2型糖尿病患者中升高，在动脉粥样硬化和心血管疾病的发病机制中起有害作用。越来越多的证据表明，血管内皮（血管的内层）功能障碍是动脉粥样硬化发病机制中的关键因素。本文就游离脂肪酸介导的内皮功能障碍的临床和实验研究进行综述。由于血浆游离脂肪酸在介导内皮功能障碍中的多方面作用，游离脂肪酸水平升高现在被认为是代谢综合征（如糖尿病和肥胖症）导致内皮功能障碍发作的重要环节。游离脂肪酸介导的内皮功能障碍涉及多种机制，包括胰岛素信号传导和一氧化氮产生受损、氧化应激、炎症和内皮细胞中的肾素-血管紧张素系统的激活以及细胞凋亡。因此，靶向参与游离脂肪酸诱导的内皮功能障碍的信号通路可以作为预防内皮功能障碍的发生和随后的并发症如动脉粥样硬化的预防方法。
Plasma free fatty acids levels are increased in subjects with obesity and type 2 diabetes, playing detrimental roles in the pathogenesis of atherosclerosis and cardiovascular diseases. Increasing evidence showing that dysfunction of the vascular endothelium, the inner lining of the blood vessels, is the key player in the pathogenesis of atherosclerosis. In this review, we aimed to summarize the roles and the underlying mechanisms using the evidence collected from clinical and experimental studies about free fatty acid-mediated endothelial dysfunction. Because of the multifaceted roles of plasma free fatty acids in mediating endothelial dysfunction, elevated free fatty acid level is now considered as an important link in the onset of endothelial dysfunction due to metabolic syndromes such as diabetes and obesity. Free fatty acid-mediated endothelial dysfunction involves several mechanisms including impaired insulin signaling and nitric oxide production, oxidative stress, inflammation and the activation of the renin-angiotensin system and apoptosis in the endothelial cells. Therefore, targeting the signaling pathways involved in free fatty acid-induced endothelial dysfunction could serve as a preventive approach to protect against the occurrence of endothelial dysfunction and the subsequent complications such as atherosclerosis.
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DOI：
10.3390/healthcare5020029
发表时间：
2017-06-21
期刊：
Healthcare (Basel, Switzerland)
影响因子：
--
作者：
Briggs MA;Petersen KS;Kris-Etherton PM
通讯作者：
Kris-Etherton PM
影响因子：
8.3
作者：
Azekoshi, Yoko;Yasu, Takanori;Ueda, Shinichiro
通讯作者：
Ueda, Shinichiro
影响因子：
5.6
作者：
Aguilar, Edenil C.;dos Santos, Lana Claudinez;Alvarez-Leite, Jacqueline I.
通讯作者：
Alvarez-Leite, Jacqueline I.
DOI：
10.1016/j.ecl.2008.06.007
发表时间：
2008-09
影响因子：
4.5
作者：
Boden, Guenther
通讯作者：
Boden, Guenther
影响因子：
4.8
作者：
Artwohl, M;Roden, M;Baumgartner-Parzer, SM
通讯作者：
Baumgartner-Parzer, SM