Women are different: the role of coupling factor 6 in blood pressure regulation.
Women are different: the role of coupling factor 6 in blood pressure regulation.
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DOI：
10.1038/hr.2012.9
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发表时间：
2012-05
影响因子：
5.4
通讯作者：
Lindsey, Merry L.
中科院分区：
文献类型：
--
作者：
de Castro Bras, Lisandra E.;DeLeon, Kristine Y.;Lindsey, Merry L.
与血压相关的疾病，特别是高血压、冠心病、心力衰竭和脑卒中是发病和死亡的主要原因。在全球范围内，血压升高占冠心病病例的47%和中风发病率的54%。1此外，全世界约13%的死亡是高血压造成的。盐的过量摄入在高血压的发病机制中起主要作用。迄今为止，已有超过50项随机试验测试了钠减少对成人血压的影响，总体共识是钠摄入量与血压具有统计学显著性，渐进性和剂量依赖性关系。每天适度减少100 mmol（6 g盐）已被证明可显著降低高血压和正常血压受试者的收缩压和舒张压。2在本期的《高血压研究》中，Izumiyama等3表明，雌激素替代对高盐饮食（HSD）下卵巢切除的女性具有心脏保护功能。此外，他们报道了偶联因子6（CF6）过度表达增加盐敏感性高血压的机制，导致心脏收缩功能障碍增强。
Blood pressure (BP)-related diseases, par-ticularly, hypertension, coronary heart disease, heart failure and stroke are the leading causes of morbidity and mortality. Worldwide, elevated BP accounts for 47% of coronary heart disease cases and 54% of stroke incidences. 1 Moreover, about 13% of total deaths worldwide are a result of hypertension. The excessive intake of salt has a major role in the pathogenesis of hypertension. To date, over 50 randomized trials have tested the effects of sodium reduction on BP in adults, with the overall consensus that sodium intake has a statistically significant, progressive and dose-dependent relationship with BP. A daily modest reduction of 100mmol (6g of salt) has been shown to significantly reduce systolic and diastolic BP in both the hypertensive and normotensive subjects. 2 In this issue of Hypertension Research, Izumiyama et al. 3 show that estrogen replacement has a cardioprotective function in ovariectomized females under a highsalt diet (HSD). Furthermore, they report on the mechanism whereby coupling factor 6 (CF6) overexpression increases salt-sensitive hypertension, resulting in enhanced cardiac systolic dysfunction.
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DOI：
10.1016/j.bbrc.2009.05.126
发表时间：
2009-08-14
影响因子：
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作者：
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通讯作者：
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DOI：
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发表时间：
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期刊：
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