Iron and immunity: immunological consequences of iron deficiency and overload.
Iron and immunity: immunological consequences of iron deficiency and overload.
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DOI：
10.1007/s00005-010-0095-9
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发表时间：
2010-12
影响因子：
3.2
通讯作者：
Cherayil, Bobby J.
中科院分区：
文献类型：
--
作者：
Cherayil, Bobby J.
铁对免疫功能的影响长期以来一直受到重视。然而，这种相互作用的分子基础还不太清楚。最近，有几个重要的进展，阐明了哺乳动物铁代谢的调节机制。新的见解为理解和操纵铁稳态和免疫系统之间的相互作用提供了一个概念框架。本文将回顾目前已知的铁代谢紊乱如何影响免疫力，以及免疫系统的激活如何导致铁平衡的改变。
The influence of iron on immune function has been long appreciated. However, the molecular basis for this interaction is less well understood. Recently, there have been several important advances that have shed light on the mechanisms that regulate mammalian iron metabolism. The new insights provide a conceptual framework for understanding and manipulating the cross-talk between iron homeostasis and the immune system. This article will review what is currently known about how disturbances of iron metabolism can affect immunity and how activation of the immune system can lead to alterations in iron balance.
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