Inhibition of cell proliferation by mechanical agitation involves transient cell cycle arrest at G1 phase in dinoflagellates
Inhibition of cell proliferation by mechanical agitation involves transient cell cycle arrest at G1 phase in dinoflagellates
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机械搅拌对细胞增殖的抑制涉及甲藻中 G1 期的短暂细胞周期停滞
DOI：
10.1007/s00709-002-0039-2
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发表时间：
2003
期刊：
影响因子：
2.9
通讯作者：
J. Wong
中科院分区：
文献类型：
--
作者：
P. Yeung;J. Wong
摘要：机械搅动对甲藻 细胞的增殖有负面影响，该组织成员引起的赤潮与平静的海况有关。机械转导抑制细胞增殖的机制被认为涉及细胞分裂装置的破坏。在这项研究中，我们使用高度同步化的细胞和流式细胞术来研究机械搅拌对细胞周期进程的影响。我们观察到机械搅拌诱导异养甲藻和光合甲藻的细胞周期短暂停滞于G1期。
Summary. Cell proliferation of dinoflagellates is negatively affected by mechanical agitation and red tides caused by members of the group have been correlated with periods of calm sea conditions. The mechanism involved in the mechanically transduced inhibition of cell proliferation is thought to involve the disruption of the cell division apparatus. In this study, we used highly synchronized cells and flow cytometry to study the effects of mechanical agitation on cell cycle progression. We observed that mechanical agitation induced transient cell cycle arrest at G1 phase, in both the heterotrophic dinoflagellate Crypthecodinium cohnii and the photosynthetic dinoflagellate Heteroscapsa triquetra.
影响因子：
56.9
作者：
HARTWELL, LH;WEINERT, TA
通讯作者：
WEINERT, TA