Cancer Immune Evasion Through Loss of MHC Class I Antigen Presentation.
Cancer Immune Evasion Through Loss of MHC Class I Antigen Presentation.
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DOI：
10.3389/fimmu.2021.636568
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发表时间：
2021
影响因子：
7.3
通讯作者：
Rock KL
中科院分区：
文献类型：
--
作者：
Dhatchinamoorthy K;Colbert JD;Rock KL
主要组织相容性 I 类 (MHC I) 分子结合源自细胞表达基因的肽，然后在细胞表面运输和展示该抗原信息。这使得 CD8 T 细胞能够识别合成异常蛋白质的病理细胞，例如表达突变蛋白质的癌症。为了使许多癌症发生和发展，它们需要进化出避免被 CD8 T 细胞消除的机制。 MHC I 分子对于细胞生存并不是必需的，因此癌症逃避免疫控制的一种机制是失去 MHC I 抗原呈递机制 (APM)。这不仅会损害自然免疫反应控制癌症的能力，还会阻碍通过重新激活抗肿瘤 CD8 T 细胞发挥作用的免疫疗法，例如检查点封锁。在这里，我们回顾了许多癌症中经常发生 MHC I 抗原呈递缺失的证据。我们讨论了一些癌症使 MHC I 途径失活的常见潜在机制的新见解，并考虑了一些可能的策略来克服这一限制，从而恢复肿瘤的免疫控制并改善免疫治疗。
Major histocompatibility class I (MHC I) molecules bind peptides derived from a cell's expressed genes and then transport and display this antigenic information on the cell surface. This allows CD8 T cells to identify pathological cells that are synthesizing abnormal proteins, such as cancers that are expressing mutated proteins. In order for many cancers to arise and progress, they need to evolve mechanisms to avoid elimination by CD8 T cells. MHC I molecules are not essential for cell survival and therefore one mechanism by which cancers can evade immune control is by losing MHC I antigen presentation machinery (APM). Not only will this impair the ability of natural immune responses to control cancers, but also frustrate immunotherapies that work by re-invigorating anti-tumor CD8 T cells, such as checkpoint blockade. Here we review the evidence that loss of MHC I antigen presentation is a frequent occurrence in many cancers. We discuss new insights into some common underlying mechanisms through which some cancers inactivate the MHC I pathway and consider some possible strategies to overcome this limitation in ways that could restore immune control of tumors and improve immunotherapy.
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DOI：
10.4049/jimmunol.1200064
发表时间：
2012-07-15
期刊：
Journal of immunology (Baltimore, Md. : 1950)
影响因子：
--
作者：
Biswas A;Meissner TB;Kawai T;Kobayashi KS
通讯作者：
Kobayashi KS
DOI：
10.4049/jimmunol.1301043
发表时间：
2013-08-15
期刊：
Journal of immunology (Baltimore, Md. : 1950)
影响因子：
--
作者：
Kanaseki T;Lind KC;Escobar H;Nagarajan N;Reyes-Vargas E;Rudd B;Rockwood AL;Van Kaer L;Sato N;Delgado JC;Shastri N
通讯作者：
Shastri N
DOI：
10.1073/pnas.1222342110
发表时间：
2013-02-26
影响因子：
11.1
作者：
Boyle, Louise H.;Hermann, Clemens;Trowsdale, John
通讯作者：
Trowsdale, John
影响因子：
--
作者：
Benitez, R;Godelaine, D;Garrido, F
通讯作者：
Garrido, F
影响因子：
4.6
作者：
Boesen, M;Svane, IM;Werdelin, O
通讯作者：
Werdelin, O