Comparison of lung T2* during free-breathing at 1.5 T and 3.0 T with ultrashort echo time imaging.
Comparison of lung T2* during free-breathing at 1.5 T and 3.0 T with ultrashort echo time imaging.
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DOI：
10.1002/mrm.22829
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发表时间：
2011-07
影响因子：
3.3
通讯作者：
Song, Hee Kwon
中科院分区：
文献类型：
--
作者：
Yu, Jiangsheng;Xue, Yiqun;Song, Hee Kwon
肺T2*的评估可能在检测肺气肿和慢性支气管炎等肺部疾病引起的结构和功能变化方面发挥重要作用。虽然已经在 1.5T 下对动物和人类进行了 T2* 测量，但尚未报道 3.0T 下对人肺的研究。本工作采用超短回波时间（UTE）成像技术对正常人肺部在1.5T和3.0T下的T2*值进行测量和比较。在模型实验中实现并评估了 2D UTE 脉冲序列，其中橡皮擦充当均匀的短 T2* 样本。在体内研究中，对五名正常人类受试者在两种场强下进行了成像并对结果进行了比较。自由呼吸期间测得的平均 T2* 值在 1.5T 时为 2.11(±0.27)ms，在 3.0T 时为 0.74(±0.1)ms，导致 3.0T/1.5T 比率为 2.9。此外，通过自门控完成的呼气末和吸气末松弛值的比较表明，在正常呼吸期间，两个阶段之间的 T2* 差异可以忽略不计。
Assessment of lung T2* may play an important role in the detection of structural and functional changes caused by lung diseases such as emphysema and chronic bronchitis. While T2* measurements have been conducted in both animals and humans at 1.5T, studies on human lung at 3.0T have not yet been reported. In this work, ultrashort echo time (UTE) imaging technique was applied for the measurement and comparison of T2* values in normal human lungs at 1.5T and 3.0T. A 2D UTE pulse sequence was implemented and evaluated in phantom experiments, in which an eraser served as a homogeneous short T2* sample. For the in vivo study, five normal human subjects were imaged at both field strengths and the results compared. The average T2* values measured during free-breathing were 2.11(±0.27)ms at 1.5T and 0.74(±0.1)ms at 3.0T, respectively, resulting in a 3.0T/1.5T ratio of 2.9. Furthermore, comparison of the relaxation values at end-expiration and end-inspiration, accomplished through self-gating, showed that during normal breathing, differences in T2* between the two phases may be negligible.
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