Spinal Sensorimotor Transformation: Relation between Cutaneous Somatotopy and a Reflex Network
Spinal Sensorimotor Transformation: Relation between Cutaneous Somatotopy and a Reflex Network
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脊髓感觉运动转化：皮肤体位与反射网络之间的关系
DOI：
10.1523/jneurosci.22-18-08170.2002
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发表时间：
2002
期刊：
影响因子：
--
通讯作者：
J. Schouenborg
中科院分区：
文献类型：
--
作者：
A. Levinsson;H. Holmberg;J. Broman;Mengliang Zhang;J. Schouenborg
初级传入信号投射到脊髓中间神经元是脊髓反射系统进行感觉运动转换的第一步。尽管对脊髓体成形术进行了广泛的研究，但关于代表性重叠的程度和意义以及与脊髓反射回路的关系仍然存在不确定性。为了解决这些问题，我们在大鼠身上研究了后爪的皮肤投影及其与编码戒断反射强度（“反射编码器”）的V层神经元地形的关系。利用小麦胚芽凝集素-辣根过氧化物酶和类霍乱素示踪分别定位了II层和III-IV层的粗端和细端传入端。这些投射的功能权重通过绘制伤害和触觉场电位来表征，并与反射编码器的地形进行比较。解剖和生理数据都表明，薄皮肤和粗皮肤的传入输入在水平面上是空间一致的。后爪在脊髓中的表现被发现是复杂的，来自不同皮肤部位的投影之间具有高度的收敛性。“体位紊乱”，如指内侧的中央垫的表现是常见的。III-IV椎板皮肤收敛模式的重量分布与V椎板反射编码器相似。这表明，皮肤的收敛和诸如躯体紊乱等特征与深背角反射中间神经元所执行的感觉运动转换有特定的关系。因此，根据这种反射系统的地形，可以更好地理解脊髓体位图。
The projection of primary afferents onto spinal interneurons constitutes the first step in sensorimotor transformations performed by spinal reflex systems. Despite extensive studies on spinal somatotopy, uncertainties remain concerning the extent and significance of representational overlap and relation to spinal reflex circuits. To address these issues, the cutaneous projection from the hindpaw and its relation to the topography of lamina V neurons encoding withdrawal reflex strength (“reflex encoders”) was studied in rats. Thin and coarse primary afferent terminations in laminas II and III–IV, respectively, were mapped by wheat germ agglutinin-horseradish peroxidase and choleragenoid tracing. The functional weights of these projections were characterized by mapping nociceptive and tactile field potentials and compared with the topography of reflex encoders. Both anatomical and physiological data indicate that thin and coarse skin afferent input is spatially congruent in the horizontal plane. The representation of the hindpaw in the spinal cord was found to be intricate, with a high degree of convergence between the projections from different skin sites. “Somatotopic disruptions” such as the representation of central pads medial to that of the digits were common. The weight distribution of the cutaneous convergence patterns in laminas III–IV was similar to that of lamina V reflex encoders. This suggests that the cutaneous convergence and features such as somatotopic disruptions have specific relations to the sensorimotor transformations performed by reflex interneurons in the deep dorsal horn. Hence, the spinal somatotopic map may be better understood in light of the topography of such reflex systems.
背根神经节逆转后胚胎鸡后肢的皮肤感觉神经支配模式。
DOI：
10.1002/neu.480170609
发表时间：
1986
期刊：
Journal of neurobiology
影响因子：
--
作者：
Scott,SA
通讯作者：
Scott,SA
猫背角后肢表征的精度和变异性以及对触觉定位的影响。
影响因子：
2.5
作者：
Koerber,HR;Hobbs,G;Brown,PB
通讯作者：
Brown,PB
雏鸡后肢发育过程中皮肤、肌肉感觉和运动神经元轴突之间的空间关系。
DOI：
10.1242/dev.125.6.995
发表时间：
1998
期刊：
Development (Cambridge, England)
影响因子：
--
作者：
Honig,MG;Frase,PA;Camilli,SJ
通讯作者：
Camilli,SJ