Characterization and quantification of oxidative stress induced particle debris from polypropylene surgical mesh
Characterization and quantification of oxidative stress induced particle debris from polypropylene surgical mesh
复制标题
聚丙烯手术网片中氧化应激诱导的颗粒碎片的表征和定量
DOI：
10.1002/nano.202200243
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发表时间：
2023
期刊：
影响因子：
--
通讯作者：
Farr N
中科院分区：
文献类型：
--
作者：
Farr N
移位的聚丙烯(PP)外科网片经常被报道出现表面变化，如裂纹和剥落。然而，到目前为止，人们还不清楚PP网状物降解的后果，特别是它对周围组织生物宿主反应的潜在影响。特别值得关注的是，通过体内外科网状物的降解释放的聚丙烯颗粒可能会发生宿主反应。这一担忧是由以前的研究驱动的，这些研究假设氧化应激环境有可能侵蚀PP纤维表面的颗粒。这种颗粒的释放具有相当重要的意义，因为纳米到微米范围的颗粒已经被证明具有刺激细胞和刺激免疫系统的能力。作者不知道以前有任何研究试图表征、量化或识别暴露在氧化应激环境中的PP网状物释放出的任何颗粒。采用低电压扫描电子显微镜(LV-SEM)、裂解气相色谱-质谱仪(PYR-GCMS)、纳米傅立叶变换红外光谱(Nano-FTIR)、散射式、扫描近场光学显微镜(S-SNOM)、原子力显微镜(AFM)、衰减全反射傅立叶变换红外光谱(ATR-FTIR)和单轴拉伸测试等技术对PP网状物进行了表征，包括颗粒的识别。这项研究的结果表明，氧化应激本身就是产生PP颗粒碎片的主要因素。用PYR-GCMS鉴定出溶液中的PP碎片为微米量级。
Explanted polypropylene (PP) surgical mesh has frequently been reported to show surface alterations, such as cracks and flaking. However, to date the consequence of PP mesh degradation is not clearly understood, particularly its potential to influence the biological host response of surrounding tissues. Of particular concern is a possible host reaction to polypropylene particles released through degradation of surgical mesh in vivo. This concern is driven by previous studies which have postulated that an oxidative stress environment has the potential to etch away particles from the surface of a PP fibers. The release of such particles is of considerable significance as particles in the nano‐ to micro range have been shown to have the capacity to irritate cells and stimulate the immune system. The authors are not aware of any previous studies that have attempted to characterize, quantify or identify any particles released from PP mesh after exposure to an oxidative stress environment. Characterization of the PP mesh, post oxidative stress exposure, including identification of particles was achieved through application of a range of techniques: low voltage‐scanning electron microscopy (LV‐SEM), pyrolysis gas chromatography mass spectrometry (Pyr‐GCMS), nano‐Fourier transform infrared spectroscopy (nano‐FTIR), scattering‐type, scanning near‐field optical microscopy (s‐SNOM), atomic force microscopy (AFM), attenuated total reflectance‐Fourier transform infrared spectroscopy (ATR‐FTIR) and uniaxial tensile testing. The findings of this study indicate that oxidative stress alone is a major factor in the production of PP particle debris. PP debris identified within solution, using Pyr‐GCMS, was shown to be in order of the micron scale.
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DOI：
10.1016/j.jmbbm.2018.08.041
发表时间：
2018
影响因子：
3.9
作者：
D. Taylor
通讯作者：
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影响因子：
14
作者：
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DOI：
--
发表时间：
1996
期刊：
影响因子：
--
作者：
T. Sundell;H. Fagerholm;H. Crozier
通讯作者：
H. Crozier
影响因子：
1.8
作者：
Margaret Thompson;S. Guelcher;R. Bendavid;V. Iakovlev;D. Ostergard
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影响因子：
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