Protecting the boundary: the sentinel role of host defense peptides in the skin.
Protecting the boundary: the sentinel role of host defense peptides in the skin.
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DOI：
10.1007/s00018-011-0712-8
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发表时间：
2011-07
影响因子：
8
通讯作者：
Gallo, Richard L.
中科院分区：
文献类型：
--
作者：
Bernard, Jamie J.;Gallo, Richard L.
皮肤是我们抵御微生物病原体的主要屏障，并已进化出先天和适应性策略，以增强对损伤或微生物侵袭的免疫力。对哺乳动物皮肤中抗菌肽（AMP）产生的研究揭示了AMP用于预防感染的几种优雅策略。AMP可由感染和损伤诱导，并通过直接杀死病原体和/或充当多功能效应分子来保护宿主，所述多功能效应分子触发细胞应答以帮助抗感染和修复应答。取决于特定的AMP，这些分子可以影响细胞因子产生、细胞迁移、细胞增殖、分化、血管生成和伤口愈合。AMP的异常产生与几种皮肤疾病的发病机制有关，并在确定患者对病原体的易感性中起作用。本文就AMP在皮肤及皮肤病中的调节和功能的研究进展作一综述。
The skin is our primary shield against microbial pathogens and has evolved innate and adaptive strategies to enhance immunity in response to injury or microbial insult. The study of antimicrobial peptide (AMP) production in mammalian skin has revealed several of the elegant strategies that AMPs use to prevent infection. AMPs are inducible by both infection and injury and protect the host by directly killing pathogens and/or acting as multifunctional effector molecules that trigger cellular responses to aid in the anti-infective and repair response. Depending on the specific AMP, these molecules can influence cytokine production, cell migration, cell proliferation, differentiation, angiogenesis and wound healing. Abnormal production of AMPs has been associated with the pathogenesis of several cutaneous diseases and plays a role in determining a patient’s susceptibility to pathogens. This review will discuss current research on the regulation and function of AMPs in the skin and in skin disorders.
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