コレステロール負荷家兎における後醗酵茶「碁石茶」の高脂血症及び動脈硬化抑制効果
コレステロール負荷家兎における後醗酵茶「碁石茶」の高脂血症及び動脈硬化抑制効果
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后发酵茶“Goishicha”对胆固醇负荷兔的高脂血症和动脉硬化的抑制作用
DOI：
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发表时间：
2008
期刊：
影响因子：
--
通讯作者：
豊弘 西岡
中科院分区：
文献类型：
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作者：
充彦 宮村;洋憲 森山;修三 邑田;淳子 横田;三郎 吉岡;大祐 宅間;篤秀 濱田;豊弘 西岡
：由于脂质氧化与高胆固醇血症相关的动脉粥样硬化的恶化有关，因此摄入具有抗氧化作用的饮料和食品有助于防止脂质氧化。五石茶是一种采用日本独特方法制造的后发酵茶，可用于预防各种疾病。然而，没有科学证据。在这项研究中，我们比较了五石茶与其他茶的自由基清除活性，并将这种茶给予高胆固醇血症兔子模型，以评估其在抑制高胆固醇血症和动脉粥样硬化方面的作用。五石茶的自由基清除活性与绿茶相似，且高于其他类型的发酵茶。另一方面，五石茶和绿茶之间的成分存在一些差异。在用胆固醇喂养的兔子中，五石茶组的低密度脂蛋白（LDL）胆固醇水平低于绿茶组。五石茶组的血浆过氧化脂质值也低于绿茶组和自来水组。主动脉内皮染色显示，五石茶组的脂肪面积低于自来水组。此外，五石茶组主动脉内膜的脂肪积累非常低。 Goishitea 比其他测试的发酵茶具有更高的抗氧化活性（其他发酵茶通常较低），并且降低了血清脂质水平，这表明 Goishitea 是一种非常奇特的发酵茶，可用于预防高胆固醇血症和动脉粥样硬化。
: Since lipid oxidation is involved in the deterioration of hypercholesterolemia-related atherosclerosis, ingestion of drinks and foods with antioxidant actions is useful for preventing lipid oxidation. Goishi-tea is a post-fermented-tea manufactured by a unique method in Japan, and may be useful for preventing various disorders. However, there is no scientific evidence. In this study, we compared the radical scavenging activity of goishi-tea with that of other teas, and administered this tea to a rabbit model of hypercholesteremia to evaluate its usefulness in the inhibition of hypercholesteremia and atherosclerosis. The radical scavenging activity of goishi-tea was similar to that of green-tea, and was higher than that of other types of fermented-teas. On the other hand, some difference of components was found between goishi-tea and green-tea. In cholesterol-fed rabbits, low-density lipoprotein (LDL)-cholesterol level in the goishi-tea-group was lower than that in the green-tea-group. Plasma lipidperoxide value was also lower in the goishi-tea-group than in the green-tea and tap-water-groups. On aortic endothelial staining, fat area in the goishi-tea-group was lower than that in the tap-water-group. Furthermore, fat accumulation in the aortic intima in the goishi-tea-group was very low. Goishi-tea has higher antioxidant activities than the other fermented-teas tested, which were generally low, and decreased serum lipid levels, suggesting that goishitea is a very peculiar fermented-tea with usefulness in the prevention of hypercholesterolemia and atherosclerosis.
超越胆固醇。
DOI：
10.1056/nejm198904063201407
发表时间：
1989
期刊：
The New England journal of medicine
影响因子：
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作者：
Steinberg,D;Parthasarathy,S;Carew,TE;Khoo,JC;Witztum,JL
通讯作者：
Witztum,JL