Control of metabolic and cardiovascular function by the leptin-brain melanocortin pathway.
Control of metabolic and cardiovascular function by the leptin-brain melanocortin pathway.
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DOI：
10.1002/iub.1187
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发表时间：
2013-08
期刊：
影响因子：
4.6
通讯作者：
Hall, John E.
中科院分区：
文献类型：
--
作者：
do Carmo, Jussara M.;da Silva, Alexandre A.;Dubinion, John;Sessums, Price O.;Ebaady, Sabira H.;Wang, Zhen;Hall, John E.
肥胖被认为是一个主要的世界性健康问题。超重是导致血压升高的最常见原因，并显著增加新陈代谢、心血管和肾脏疾病的风险。虽然肥胖症与高血压之间的联系机制尚未完全阐明，但交感神经系统(SNS)活性增加是肥胖者血压升高的原因之一。最近的证据表明，瘦素和中枢神经系统(CNS)的黑素皮质素系统，包括黑素皮质素4受体(MC4R)，在肥胖与SNS活性增加和高血压之间起着关键作用。瘦素是一种由脂肪组织产生的多肽激素，它穿过血脑屏障，通过中枢黑素皮质素系统激活大脑中枢，控制多种代谢功能以及SNS活动和BP。外周信号(如瘦素)与调节能量平衡、SNS活性和血压的中枢神经系统通路(如MC4R)之间的串扰是治疗肥胖及其代谢和心血管后果的重要靶点。
Obesity is recognized as a major worldwide health problem. Excess weight gain is the most common cause of elevated blood pressure (BP) and markedly increases the risk of metabolic, cardiovascular and renal diseases. Although the mechanisms linking obesity with hypertension have not been fully elucidated, increased sympathetic nervous system (SNS) activity contributes to elevated BP in obese subjects. Recent evidence indicates that leptin and the central nervous system (CNS) melanocortin system, including melanocortin 4 receptors (MC4R), play a key role in linking obesity with increased SNS activity and hypertension. Leptin, a peptide-hormone produced by adipose tissue, crosses the blood–brain barrier and activates brain centers that control multiple metabolic functions as well as SNS activity and BP via the CNS melanocortin system. The crosstalk between peripheral signals (e.g., leptin) and activation of CNS pathways (e.g., MC4R) that regulate energy balance, SNS activity and BP represents an important target for treating obesity and its metabolic and cardiovascular consequences.
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DOI：
10.1152/ajpregu.00392.2011
发表时间：
2012-03-01
影响因子：
2.8
作者：
do Carmo, Jussara M.;da Silva, Alexandre A.;Hall, John E.
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影响因子：
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发表时间：
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影响因子：
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影响因子：
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作者：
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影响因子：
158.5
作者：
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