The role of metabolic disorders in Alzheimer disease and vascular dementia: two roads converged.
The role of metabolic disorders in Alzheimer disease and vascular dementia: two roads converged.
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DOI：
10.1001/archneurol.2009.27
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发表时间：
2009-03
影响因子：
--
通讯作者：
Craft, Suzanne
中科院分区：
文献类型：
--
作者：
Craft, Suzanne
近年来，越来越多的研究集中在痴呆症与糖尿病、肥胖、高血压和血脂异常等代谢疾病之间的关系。病因学的异质性和共病给确定代谢紊乱之间的关系带来了挑战。事实证明，脑血管损伤和Aβ等经典病原体的独立和交互作用在人类患者中也很难理清，模糊了阿尔茨海默病和血管性痴呆之间的界限。这篇综述重点介绍了最近的工作，旨在确定诸如胰岛素抵抗等趋同机制，这些机制可能是共病代谢紊乱的基础，从而增加痴呆症的风险。识别这种趋同因素不仅将为晚年痴呆的原因和相互依赖提供重要的见解，而且还将启发治疗和预防这些疾病的新策略。
In recent years, there has been a rapidly increasing number of studies focused on the relationship between dementia and metabolic disorders such as diabetes, obesity, hypertension and dyslipidemia. Etiological heterogeneity and co-morbidity pose challenges for determining relationships among metabolic disorders. The independent and interactive effects of brain vascular injury and classic pathological agents such as Aβ have also proved difficult to untangle in human patients, blurring the lines between Alzheimer's disease and vascular dementia. This review highlights recent work aimed at identifying convergent mechanisms such as insulin resistance that may underlie co-morbid metabolic disorders and thereby increase dementia risk. Identification of such convergent factors will not only provide important insights into the causes and interdependencies of late-life dementias, but will also inspire novel strategies for treating and preventing these disorders.
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