Urinary leukotriene E4 in patients with asthma. Effect of airways reactivity and sodium cromoglycate.
Urinary leukotriene E4 in patients with asthma. Effect of airways reactivity and sodium cromoglycate.
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哮喘患者的尿白三烯 E4。
DOI：
10.1164/ajrccm/143.6.1322
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发表时间：
1991
期刊：
影响因子：
--
通讯作者：
Voelkel,NF
中科院分区：
文献类型：
--
作者：
Westcott,JY;Smith,HR;Wenzel,SE;Larsen,GL;Thomas,RB;Felsien,D;Voelkel,NF
用雾化抗原激发17例过敏性哮喘患者，测定尿白三烯代谢产物白三烯E的排泄量作为白三烯合成的指标。过敏原激发导致所有患者的FEY在最初的2小时内下降了25%至59%。这与尿液LTE的增加有关。在随后的12小时内排泄。尿液LTE的量。排泄量从12小时基线水平46±6.8 ng增加到促过敏原激发水平92±13 ng。在类似的实验方案中，单用乙酰甲胆碱激发并不能显着增加尿LTE。排泄物。在将所有个体作为一个整体进行比较时，在即刻哮喘反应(IAR)期间FEY下降的幅度与LTE的增量之间没有显著的正相关。经尿液排泄(p=0.08)。当也考虑呼吸道反应性时，这些参数仍然没有显著相关性(p=0.057)。然而，当每个个体在存在和不存在色甘酸的情况下与自身进行比较时，发现在IAR期间FEY1的下降、尿液LTE的排泄和呼吸道反应性之间存在显著的相关性。未发现尿LTE增加之间的相关性。尿LTE在过敏原激发后12h排泄，后期(3~12h)反应严重，但尿液LTE显著延长(12~36h)。排泄在那些对哮喘反应最严重的患者身上。这些结果表明，在过敏性哮喘反应过程中，呼吸道内白三烯的合成增加，这种增加的合成可能与观察到的一些症状有关。Am Rev Respir DIS 1991；143：1322-1328
SUMMARY A group of 17patients with allergic asthma was challenged With aerosolized antigen, and the excretion of the peptldoleukotrlene metabolite leukotrlene (LT) E. In the urine was determined as an Index of leukotrlene synthesis. The allergen challenge caused a drop In FEY, of 25 to 59% within the first 2 h In all patients. This was associated with an Increase In urine LTE. excretion during the SUbsequent 12 h. The amount of urinary LTE. excreted increased from a 12-h baseline level of 46±6.8 ng to apostallergen challenge level of 92±13ng. In a similar experimental protocol methacholine challenge alone did not significantly Increase urinary LTE. excretion. In comparing all Individuals as a group, there was no significant positive correlation between the magnitude of the drop in FEY, during the immediate asthmatic response (IAR) and the Incre!'sed amount of LTE. excreted In the urine (p= 0.08). These parameters ware stili not significantly correlated when airways reactivity (log PC,,) was also considered (p= 0.057). However, when each Individual was compared to self In the presence and absence of cromoglycate, a significant correlation was found to exist between the drop In FEY1 during the IAR, the excretion of urinary LTE., and the airways reactivity. No correlation was found between the Increase In urine LTE. excreted during the 12h following allergen challenge and the severity of late (3 to 12 h) responses to allergen, but there was a significant prolonged (12to 36 h) eleveted urine LTE. excretion In those patients with the most severe late asthmatic response. These results suggest that leukotrlene synthesis In the airways Is Increased during allergic asthmatic reactions and this Increased synthesis may mediate some of the symptoms observed. AM REV RESPIR DIS 1991; 143: 1322-1328
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吸入白三烯 D4、组胺或抗原对豚鼠中央和外周气道的影响：用交互式图像分析系统分析支气管图。
影响因子：
5
作者：
Y. Ashida;M. Nomura;H. Kuriki;Y. Maki
通讯作者：
Y. Maki
吸入白三烯 D4 对人体呼吸道的影响
影响因子：
5.2
作者：
Lewis J. Smith;R. Patterson;R. Kern;R. Krell;Peter R. Bernstein
通讯作者：
Peter R. Bernstein
DOI：
10.1164/ajrccm/142.1.112
发表时间：
1990-07
期刊：
The American review of respiratory disease
影响因子：
--
作者：
Sally E. Wenzel;Gary L. Larsen;Karen Johnston;Norbert F. Voelkel;Jay Y. Westcott
通讯作者：
Sally E. Wenzel;Gary L. Larsen;Karen Johnston;Norbert F. Voelkel;Jay Y. Westcott
口服活性白三烯 (LT) D4 拮抗剂 WY-48, 252 对过敏性绵羊中 LTD4 和抗原诱导的支气管收缩的影响。
DOI：
10.1016/0090-6980(88)90146-3
发表时间：
1988
期刊：
Prostaglandins
影响因子：
--
作者：
Abraham,WM;Stevenson,JS;Garrido,R
通讯作者：
Garrido,R
DOI：
10.1164/ajrccm/140.2.350
发表时间：
1989-08-01
期刊：
AMERICAN REVIEW OF RESPIRATORY DISEASE
影响因子：
--
作者：
JOSEPHS, LK;GREGG, I;HOLGATE, ST
通讯作者：
HOLGATE, ST