Multisynaptic inputs from the medial temporal lobe to V4 in macaques.
Multisynaptic inputs from the medial temporal lobe to V4 in macaques.
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DOI：
10.1371/journal.pone.0052115
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发表时间：
2012
期刊：
影响因子：
3.7
通讯作者：
Takada M
中科院分区：
文献类型：
--
作者：
Ninomiya T;Sawamura H;Inoue K;Takada M
采用狂犬病病毒逆行跨突触运输的方法，对日本猕猴(Macaca Fuscata)枕颞区视觉通路的内侧颞叶(MTL)到视觉V4区进行自上而下的投射。在V4注射狂犬病后第3天，在与V4有直接联系的颞叶区域，包括海马旁皮质的Tf区，神经元标记明显。此外，明显的神经元标记出现在双突触出现在海马旁皮质的TH区，以及周围皮质的第35和36区。标记神经元主要位于深层。在注射狂犬病后的第4天，在海马区结构中发现标记神经元，同时在海马区和大脑皮质周围也发现大量标记神经元。在海马结构中，内嗅皮层的第5层神经元标记最密集，其他区域如下丘脑复合体和CA1、CA3区也有少量神经元标记。目前的结果表明，V4通过内嗅皮层接受来自海马体本身的主要输入，以及绕过内嗅皮层的“捷径”。这些多突触通路可能为涉及较低视觉区域的海马-皮质相互作用定义了解剖学基础。从MTL到V4的多突触输入可能提供有关物体识别的助记信息，这是通过枕颞叶通路完成的。
Retrograde transsynaptic transport of rabies virus was employed to undertake the top-down projections from the medial temporal lobe (MTL) to visual area V4 of the occipitotemporal visual pathway in Japanese monkeys (Macaca fuscata). On day 3 after rabies injections into V4, neuronal labeling was observed prominently in the temporal lobe areas that have direct connections with V4, including area TF of the parahippocampal cortex. Furthermore, conspicuous neuron labeling appeared disynaptically in area TH of the parahippocampal cortex, and areas 35 and 36 of the perirhinal cortex. The labeled neurons were located predominantly in deep layers. On day 4 after the rabies injections, labeled neurons were found in the hippocampal formation, along with massive labeling in the parahippocampal and perirhinal cortices. In the hippocampal formation, the densest neuron labeling was seen in layer 5 of the entorhinal cortex, and a small but certain number of neurons were labeled in other regions, such as the subicular complex and CA1 and CA3 of the hippocampus proper. The present results indicate that V4 receives major input from the hippocampus proper via the entorhinal cortex, as well as “short-cut” pathways that bypass the entorhinal cortex. These multisynaptic pathways may define an anatomical basis for hippocampal-cortical interactions involving lower visual areas. The multisynaptic input from the MTL to V4 is likely to provide mnemonic information about object recognition that is accomplished through the occipitotemporal pathway.
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