Age dependence of oval cell responses and bile duct carcinomas in male fischer 344 rats fed a cyclic choline-deficient, ethionine-supplemented diet.
Age dependence of oval cell responses and bile duct carcinomas in male fischer 344 rats fed a cyclic choline-deficient, ethionine-supplemented diet.
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DOI：
10.1002/hep.23880
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发表时间：
2010-11
期刊：
影响因子：
13.5
通讯作者：
Sell, Stewart
中科院分区：
文献类型：
--
作者：
Guest, Ian;Ilic, Zoran;Sell, Stewart
The age dependence of the oval cell response and bile duct carcinomas of male F344 rats exposed to 2 weeks on-1 week off cyclic CDE diet supports the concept of loss of potential of liver stem cells to form cancers with aging. Livers of rats exposed at 3 weeks of age demonstrated a robust and wide-spread oval cell proliferation followed by cholangiofibrosis and bile duct metaplasia with extensive mucinous cysts throughout all lobes, and induction of cholangiocarcinomas (CCAs) in 7/8 rats. Livers of rats exposed beginning at 8 weeks of age had much less oval cell response and cholangiofibrosis with only 1/15 rats developing a CCA. Livers in old (10–12 months when started) rats remained virtually unaffected, with minimal oval cell proliferation, only occasional and small foci of ductular dysplasia and 0/16 CCAs. In contrast to most published studies using uninterrupted CD plus a carcinogen, hepatocellular carcinoma was not observed under the conditions of this study. The week off during cyclic CDE may allow putative liver stem cells to avoid death or differentiation and survive to give rise to CCAs, whereas with continuous CDE exposure the stem cells are forced to differentiate and give rise to HCCs and relatively few CCAs.
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DOI：
10.1111/j.1749-6632.2003.tb03247.x
发表时间：
2003-01-01
期刊：
HEMATOPOIETIC STEM CELLS 2002: GENETICS AND FUNCTION
影响因子：
--
作者：
Kim, M;Moon, HM;Spangrude, GJ
通讯作者：
Spangrude, GJ
影响因子：
64.8
作者：
Rossi, Derrick J.;Bryder, David;Weissman, Irving L.
通讯作者：
Weissman, Irving L.
影响因子：
13.5
作者：
Crosby, HA;Hubscher, SG;Strain, AJ
通讯作者：
Strain, AJ
影响因子：
6.4
作者：
LOMBARDI, B;SHINOZUKA, H
通讯作者：
SHINOZUKA, H
影响因子：
13.5
作者：
Radaeva, S;Ferreira-Gonzalez, A;Sirica, AE
通讯作者：
Sirica, AE