Multi-modal MRI reveals changes in placental function following preterm premature rupture of membranes.
Multi-modal MRI reveals changes in placental function following preterm premature rupture of membranes.
复制标题
DOI：
10.1002/mrm.29483
复制
发表时间：
2023-03
影响因子：
3.3
通讯作者：
Story, Lisa
中科院分区：
文献类型：
--
作者：
Hutter, Jana;Slator, Paddy J.;Zampieri, Carla Avena;Hall, Megan;Rutherford, Mary;Story, Lisa
胎膜早破会使40%的早产复杂化。在没有产妇症状的情况下，可能会发生胎儿感染，延误诊断，增加发病率和死亡率。因此，迫切需要对胎盘炎症的早期迹象进行无创性产前评估。16名早产儿胎膜早破及 、孕34 周的妇女和60名未合并妊娠的妇女被前瞻性纳入研究。在临床3Tesla磁共振扫描仪上获得了改进的扩散加权自旋回波单次激发增强序列，其扩散准备在~lt； 9分钟内获得了264个唯一参数组合。将数据拟合到包含快速和缓慢循环液池的两室-体素内非相干运动模型中，以获得关于灌注、密度和组织成分的定量信息。计算Z值，并评估从胎膜破裂到扫描的时间、分娩时的孕周和扫描到分娩之间的时间的相关性。胎盘在早产儿胎膜早破时显著减少，二室模型显示这种减少主要与胎盘实质中观察到的灌流成分有关。胎盘功能的多模式MRI测量与分娩时的胎龄和胎膜破裂的时间有关。与单个单一对比模型相比，更复杂的模型和数据获取可能会改进对早产潜在病因的拟合，并有助于在未来获得更多的见解。这将需要在更大的队列中进行验证。胎膜破裂和分娩之间的多模式MRI采集可用于测量胎盘功能，并与分娩时的孕周有关。
Preterm premature rupture of membranes complicates up to 40% of premature deliveries. Fetal infection may occur in the absence of maternal symptoms, delaying diagnosis and increasing morbidity and mortality. A noninvasive antenatal assessment of early signs of placental inflammation is therefore urgently required. Sixteen women with preterm premature rupture of membranes < 34 weeks gestation and 60 women with uncomplicated pregnancies were prospectively recruited. A modified diffusion‐weighted spin‐echo single shot EPI sequence with a diffusion preparation acquiring 264 unique parameter combinations in < 9 min was obtained on a clinical 3 Tesla MRI scanner. The data was fitted to a 2‐compartment ‐intravoxel incoherent motion model comprising fast and slowly circulating fluid pools to obtain quantitative information on perfusion, density, and tissue composition. Z values were calculated, and correlation with time from between the rupture of membranes and the scan, gestational age at delivery, and time between scan and delivery assessed. Placental was significantly reduced in preterm premature rupture of membranes, and the 2‐compartmental model demonstrated that this decline is mainly linked to the perfusion component observed in the placental parenchyma. Multi‐modal MRI measurement of placental function is linked to gestational age at delivery and time from membrane rupture. More complex models and data acquisition can potentially improve fitting of the underlying etiology of preterm birth compared with individual single‐contrast models and contribute to additional insights in the future. This will need validation in larger cohorts. A multi‐modal MRI acquisition between rupture of the membranes and delivery can be used to measure placental function and is linked to gestational age at delivery.
登录
查看更多内容
影响因子：
3.5
作者：
Garyfallidis E;Brett M;Amirbekian B;Rokem A;van der Walt S;Descoteaux M;Nimmo-Smith I;Dipy Contributors
通讯作者：
Dipy Contributors
影响因子：
3.8
作者：
Ho A;Hutter J;Slator P;Jackson L;Seed PT;Mccabe L;Al-Adnani M;Marnerides A;George S;Story L;Hajnal JV;Rutherford M;Chappell LC
通讯作者：
Chappell LC
影响因子：
3.3
作者：
Hutter, Jana;Price, Anthony N.;Hajnal, Joseph V.
通讯作者：
Hajnal, Joseph V.
影响因子：
3.8
作者：
Deloison, Benjamin;Salomon, Laurent J.;Siauve, Nathalie
通讯作者：
Siauve, Nathalie
影响因子：
168.9
作者：
Morris, Jonathan M.;Roberts, Christine L.;Crowther, Caroline A.
通讯作者：
Crowther, Caroline A.