Exposure to silicates and systemic autoimmune-related outcomes in rodents: a systematic review.
Exposure to silicates and systemic autoimmune-related outcomes in rodents: a systematic review.
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DOI：
10.1186/s12989-021-00439-6
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发表时间：
2022-01-07
影响因子：
10
通讯作者：
Hoet PHM
中科院分区：
文献类型：
--
作者：
Janssen LMF;Ghosh M;Lemaire F;Michael Pollard K;Hoet PHM
自身免疫可能是遗传背景与环境和/或职业暴露于有害物质的影响之间的相互作用造成的。根据流行病学证据，包括二氧化硅粉尘在内的几种化合物与全身性自身免疫和全身性自身免疫疾病有关。对于石棉，与系统性自身免疫性疾病的密切联系尚不存在，然而，一些研究已经记录了石棉暴露后自身免疫的特征。即便如此，人类研究在识别和检查孤立暴露方面的能力有限，因此难以证明因果关系或评估致病机制。因此，本系统性综述检查了现有的关于自身免疫和暴露于硅酸盐（二氧化硅和石棉）的动物证据。系统检索PubMed和EMBASE，以获得同行评审的研究，这些研究检查了啮齿动物暴露于硅酸盐后的全身性自身免疫性疾病相关结局。检索了截至2021年9月的文献数据库，以查找以英语撰写的研究，并获得全文。基于PECO（人群、暴露、对照、结局）格式建立检索字符串。在标题、摘要和全文筛选后，确定了34项研究进行进一步分析。通过ToxR工具进行质量评估，并对结果进行定性分析。尽管纳入的研究在暴露方案和所用啮齿动物模型的遗传背景方面存在显著异质性，但注意到遗传背景和硅酸盐[（结晶）二氧化硅和石棉]暴露与（亚）临床全身性自身免疫性疾病的发生高度相关。平行的观察结果之间的动物（本综述）和人类（流行病学）的研究，认为实验动物模型是有价值的工具，检查硅酸盐暴露后的自身免疫性疾病的恶化或发展。然而，遗传背景和暴露之间的协同作用应在未来的研究中加以考虑。在线版本包含补充材料，可通过10.1186/s12989-021-00439-6获得。
Autoimmunity can result from the interplay between genetic background and effects of environmental and/or occupational exposure to hazardous materials. Several compounds, including silica dust, have been linked with systemic autoimmunity and systemic autoimmune diseases, based on epidemiological evidence. For asbestos, a strong link with systemic autoimmune diseases does not yet exist, however, several studies have documented features of autoimmunity following asbestos exposure. Even so, human studies are limited in their ability to identify and examine isolated exposures, making it difficult to demonstrate causation or to assess pathogenic mechanisms. Therefore, this systematic review examines the existing animal evidence regarding autoimmunity and exposure to silicates (silica and asbestos). PubMed and EMBASE were systematically searched for peer-reviewed studies examining systemic autoimmune disease-related outcomes after silicate exposure in rodents. Literature databases were searched up to September 2021 for studies written in English and where the full text was available. Search strings were established based on a PECO (Population, Exposure, Comparator, Outcome) format. After title, abstract, and full-text screening, thirty-four studies were identified for further analysis. Quality assessment through ToxR tool and qualitative analysis of the results was performed. Although there was significant heterogeneity in the included studies in terms of exposure protocol and genetic background of the rodent models used, it was noted that both genetic background and exposure to silicates [(crystalline) silica and asbestos] are highly relevant to the development of (sub-) clinical systemic autoimmune disease. Parallels were observed between the findings from the animal (this review) and human (epidemiological) studies, arguing that experimental animal models are valuable tools for examining exacerbation or development of autoimmune disease after silicate exposure. However, genetic background and synergism between exposures should be considered in future studies. The online version contains supplementary material available at 10.1186/s12989-021-00439-6.
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DOI：
10.1186/s12952-017-0071-6
发表时间：
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期刊：
JOURNAL OF NEGATIVE RESULTS IN BIOMEDICINE
影响因子：
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