Serum carotenoids and cancer-related fatigue: An analysis of the 2005-2006 National Health and Nutrition Examination Survey.
Serum carotenoids and cancer-related fatigue: An analysis of the 2005-2006 National Health and Nutrition Examination Survey.
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DOI：
10.1158/2767-9764.crc-21-0172
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发表时间：
2022-03
期刊：
影响因子：
--
通讯作者：
Peppone, Luke J.
中科院分区：
文献类型：
--
作者：
Kleckner, Amber S.;van Wijngaarden, Edwin;Jusko, Todd A.;Kleckner, Ian R.;Lin, Po -Ju;Mustian, Karen M.;Peppone, Luke J.
癌症相关的疲劳是一种普遍的、使人衰弱的疾病，初步证据表明，较高的饮食质量和较低的疲劳之间存在关系。血清类胡萝卜素、维生素A和维生素E是水果和蔬菜摄入量的生物标志物，因此也是饮食质量的生物标志物。为了进一步阐明饮食质量与癌症相关疲劳之间的联系，在美国成年人中评估了这些血清营养素与疲劳之间的关联，特别关注癌症史。数据来自美国2005-2006年国家健康和营养调查（NHANES）数据集。从空腹血液样本中测量10种类胡萝卜素、维生素A、维生素E和γ-生育酚，并报告患者疲劳。类胡萝卜素浓度和疲劳之间的关联估计使用有序逻辑回归模型。调整后的模型包括癌症诊断（非黑色素瘤皮肤癌除外，是/否）、年龄、体重指数、人种/种族、教育和运动习惯作为协变量，其他模型包括癌症×营养相互作用。在4091名参与者中，272名（8.0%）报告了癌症病史。在调整潜在混杂因素的单独模型中，更大的疲劳与更低的血清反式番茄红素、棕榈酸视黄酯和硬脂酸视黄酯相关（所有p<0.05）。对于这些营养素，营养素增加一个标准差与更大疲劳的风险降低6.8-9.9%相关。仅在癌症幸存者（n=272）中，未观察到任何营养素与疲劳之间存在统计学显著相关性。总之，类胡萝卜素生物标志物的血清浓度越高，疲劳程度越低。这些结果支持进一步探索类胡萝卜素摄入量，饮食质量和持续性疲劳之间的关系。
Cancer-related fatigue is a prevalent, debilitating condition, and preliminary evidence suggests a relationship between higher diet quality and lower fatigue. Serum-based carotenoids, Vitamin A, and Vitamin E are biomarkers of fruit and vegetable intake and therefore diet quality. To further elucidate the link between diet quality and cancer-related fatigue, associations were assessed between these serum-based nutrients and fatigue among American adults with special attention to cancer history. Data were analyzed from the United States 2005–2006 National Health and Nutrition Examination Survey (NHANES) dataset. Ten carotenoids, vitamin A, vitamin E, and γ-tocopherol were measured from fasting blood samples and fatigue was patient-reported. Associations between carotenoid concentration and fatigue were estimated using ordinal logistic regression models. Adjusted models included a diagnosis of cancer (with the exception on non-melanoma skin cancer, yes/no), age, body mass index, race/ethnicity, education, and exercise habits as covariates, and additional models included a cancer×nutrient interaction. Of 4091 participants, 272 (8.0%) reported a history of cancer. Greater fatigue was associated with lower serum trans-lycopene, retinyl palmitate, and retinyl stearate (all p<0.05) in separate models adjusting for potential confounders. For these nutrients, a one-standard deviation increase in nutrient was associated with a 6.8–9.9% lower risk of greater fatigue. Among cancer survivors only (n=272), statistically significant associations were not observed between any of the nutrients and fatigue. In conclusion, greater serum concentrations of carotenoid biomarkers were associated with less fatigue. These results support further exploration into relationships between carotenoid intake, diet quality, and persistent fatigue.
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