Serum nutritional biomarkers and their associations with sleep among US adults in recent national surveys.
Serum nutritional biomarkers and their associations with sleep among US adults in recent national surveys.
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DOI：
10.1371/journal.pone.0103490
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发表时间：
2014
期刊：
影响因子：
3.7
通讯作者：
Zonderman AB
中科院分区：
文献类型：
--
作者：
Beydoun MA;Gamaldo AA;Canas JA;Beydoun HA;Shah MT;McNeely JM;Zonderman AB
营养生物标志物与睡眠数量和质量测量之间的关联仍不清楚。使用了2005-2006年国家健康和营养检查调查（NHANES）的横截面数据。我们选择了2，459名年龄在20-85岁之间的成年人，并提供了关键变量的完整数据。五个睡眠指标被构建为主要结果：（A）睡眠持续时间;（B）睡眠障碍;（C）从15个项目的因子分析中获得的三个因子，并标记为“睡眠相关的日间功能障碍差”（因子1）、“嗜睡”（因子2）和“睡眠障碍”（因子3）。主要暴露是关键营养素的血清浓度，即视黄醇、视黄酯、类胡萝卜素（α-胡萝卜素、β-胡萝卜素、β-隐黄质、叶黄素+玉米黄质、番茄红素）、叶酸、维生素B-12、总同型半胱氨酸（tHcy）、维生素C、25-羟基维生素D（25（OH）D）和维生素E。主要分析包括多重线性、逻辑和多项logit模型。在主要研究结果中，发现血清维生素B-12与睡眠时间、25（OH）D与嗜睡（以及失眠）、叶酸与睡眠障碍之间存在独立的负相关。与正常睡眠时间（每晚7-8小时）相比，血清总类胡萝卜素浓度与短睡眠时间（即每晚5-6小时）的可能性更高有关。一些选定的血清营养生物标志物与睡眠数量和质量相关。需要进行纵向研究以确定时间性并评估假定的因果关系。
The associations between nutritional biomarkers and measures of sleep quantity and quality remain unclear. Cross-sectional data from the National Health and Nutrition Examination Surveys (NHANES) 2005–2006 were used. We selected 2,459 adults aged 20–85, with complete data on key variables. Five sleep measures were constructed as primary outcomes: (A) Sleep duration; (B) Sleep disorder; (C) Three factors obtained from factor analysis of 15 items and labeled as “Poor sleep-related daytime dysfunction” (Factor 1), “Sleepiness” (Factor 2) and “Sleep disturbance” (Factor 3). Main exposures were serum concentrations of key nutrients, namely retinol, retinyl esters, carotenoids (α-carotene, β-carotene, β-cryptoxanthin, lutein+zeaxanthin, lycopene), folate, vitamin B-12, total homocysteine (tHcy), vitamin C, 25-hydroxyvitamin D (25(OH)D) and vitamin E. Main analyses consisted of multiple linear, logistic and multinomial logit models. Among key findings, independent inverse associations were found between serum vitamin B-12 and sleep duration, 25(OH)D and sleepiness (as well as insomnia), and between folate and sleep disturbance. Serum total carotenoids concentration was linked to higher odds of short sleep duration (i.e. 5–6 h per night) compared to normal sleep duration (7–8 h per night). A few of the selected serum nutritional biomarkers were associated with sleep quantity and quality. Longitudinal studies are needed to ascertain temporality and assess putative causal relationships.
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影响因子：
4.2
作者：
Beydoun, May A.;Shroff, Monal R.;Zonderman, Alan B.
通讯作者：
Zonderman, Alan B.
影响因子：
7.1
作者：
Beydoun, May A.;Ding, Eric L.;Zonderman, Alan B.
通讯作者：
Zonderman, Alan B.
影响因子：
4.2
作者：
Cherubini, A;Martin, A;Ferrucci, L
通讯作者：
Ferrucci, L
影响因子：
6.9
作者：
Day, Regina M.;Matus, Ismael A.;Tang, Guangwen
通讯作者：
Tang, Guangwen
影响因子：
4.2
作者：
Beydoun, May A.;Kuczmarski, Marie T. Fanelli;Zonderman, Alan B.
通讯作者：
Zonderman, Alan B.