Printed Electroceutical Dressings for the Inhibition of Biofilms and Treatment of Chronic Wounds.
Printed Electroceutical Dressings for the Inhibition of Biofilms and Treatment of Chronic Wounds.
复制标题
DOI：
10.1109/jmems.2020.2999260
复制
发表时间：
2020-10
期刊：
影响因子：
--
通讯作者：
Prakash S
中科院分区：
文献类型：
--
作者：
Heald R;Bennett M;Subramaniam VV;Dusane D;Lochab V;Sundaram PM;Salyer S;West JD;Stoodley P;Prakash S
我们报告了一种创新的，基于织物的舒适，易于制造的电伤口敷料，可抑制细菌生物膜感染，并显示出显著的希望愈合慢性伤口。循环伏安法证明了电解质产生活性氧物质的能力，主要是负责细菌抑制的HOCl。在软组织模拟试验上生长的菌苔生物膜的体外研究表明，敷料对生物膜形式的革兰氏阳性菌和革兰氏阴性菌均有效。在体内，将打印的电致变色敷料用作因持续一年的多微生物感染而导致伤口不愈合的犬受试者的干预治疗。犬受试者的临床病例研究显示了在临床环境中的适用性，结果显示在初始治疗的11天内抑制了感染。这种印刷的电化学敷料与蓝牙®启用电路集成，允许远程监测伤口床内的电流。利用蓝牙电路远程实时监测伤口的可能性提出了一种新的物理生物标志物，用于管理感染的慢性伤口。
We report on an innovative, fabric-based conformable, and easily fabricated electroceutical wound dressing that inhibits bacterial biofilm infections and shows significant promise for healing chronic wounds. Cyclic voltammetry demonstrates the ability of the electroceutical to produce reactive oxygen species, primarily HOCl that is responsible for bacterial inhibition. In vitro investigation with the lawn biofilm grown on a soft tissue mimic assay shows the efficacy of the dressing against both gram-positive and gram-negative bacteria in the biofilm form. In vivo, the printed electroceutical dressing was utilized as an intervention treatment for a canine subject with a non-healing wound due to a year-long persistent polymicrobial infection. The clinical case study with the canine subject exhibited the applicability in a clinical setting with the results showing infection inhibition within 11 days of initial treatment. This printed electroceutical dressing was integrated with a Bluetooth® enabled circuit allowing remote monitoring of the current flow within the wound bed. The potential to monitor wounds remotely in real-time with a Bluetooth® enabled circuit proposes a new physical biomarker for management of infected, chronic wounds.
登录
查看更多内容
影响因子：
3
作者：
Elgrishi, Noemie;Rountree, Kelley J.;Dempsey, Jillian L.
通讯作者：
Dempsey, Jillian L.
影响因子：
3.2
作者：
Chang, W;Small, DA;Bentley, WE
通讯作者：
Bentley, WE
DOI：
10.1038/nrmicro.2017.99
发表时间：
2017-12
期刊：
Nature reviews. Microbiology
影响因子：
--
作者：
Koo H;Allan RN;Howlin RP;Stoodley P;Hall-Stoodley L
通讯作者：
Hall-Stoodley L
影响因子：
9.2
作者：
Sultana ST;Call DR;Beyenal H
通讯作者：
Beyenal H
影响因子：
3.7
作者：
Sandvik, Elizabeth L.;McLeod, Bruce R.;Stewart, Philip S.
通讯作者：
Stewart, Philip S.