Early age at first sexual intercourse and early pregnancy are risk factors for cervical cancer in developing countries.
Early age at first sexual intercourse and early pregnancy are risk factors for cervical cancer in developing countries.
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DOI：
10.1038/sj.bjc.6604974
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发表时间：
2009-04-07
影响因子：
8.8
通讯作者：
Bosch, F. X.
中科院分区：
文献类型：
--
作者：
Louie, K. S.;de Sanjose, S.;Diaz, M.;Castellsague, X.;Herrero, R.;Meijer, C. J.;Shah, K.;Franceschi, S.;Munoz, N.;Bosch, F. X.
早龄性交(AFSI)长期以来一直与浸润性宫颈癌(ICC)的风险增加有关。首次怀孕年龄(AFP)和ICC的研究较少，尽管AFSI和AFP在大多数发展中国家有很强的相关性。对来自8个发展中国家的1864例病例和1719例对照的ICC病例对照研究进行了汇集分析，调查了AFSI、AFP和ICC风险的作用。首次性交年龄、AFP和初婚年龄(AFM)高度相关，并具有相似的ICC风险估计。与21岁⩾患者相比，17~20岁AFSI患者发生ICC的优势比(OR)为1.8(95%CI：1.5~2.39)，16岁AFSI患者发生ICC的OR值为2.31(95%CI：1.85~2.87)(P-Trend<；0.001)。AFSI和任何已确定的ICC危险因素之间没有发现统计学上的交互作用。在那些在⩽16年报告AFSI和AFP的患者中，与那些在⩾21年报告AFSI和AFP的患者相比，ICC风险是2.4%。这些数据证实AFSI和AFB是八个发展中国家ICC的危险因素，但这两个事件的任何独立影响无法区分。
Early age at first sexual intercourse (AFSI) has long been associated with an increased risk of invasive cervical carcinoma (ICC). Age at first pregnancy (AFP) and ICC have been investigated less, although AFSI and AFP are strongly interrelated in most developing countries. A pooled analysis of case–control studies on ICC from eight developing countries with 1864 cases and 1719 controls investigated the roles of AFSI, AFP, and ICC risk. Age at first sexual intercourse, AFP and age at first marriage (AFM) were highly interrelated and had similar ICC risk estimates. Compared with women with AFSI ⩾21 years, the odds ratio (OR) of ICC was 1.80 (95% CI: 1.50–2.39) among women with AFSI 17–20 years and 2.31 (95% CI: 1.85–2.87) for AFSI ⩽16 years (P-trend <0.001). No statistical interaction was detected between AFSI and any established risk factors for ICC. The ICC risk was 2.4-fold among those who reported AFSI and AFP at ⩽16 years compared with those with AFSI and AFP at ⩾21 years. These data confirm AFSI and AFB as risk factors for ICC in eight developing countries, but any independent effects of these two events could not be distinguished.
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影响因子：
8.8
作者：
通讯作者：
--
影响因子：
8.8
作者：
Eluf-Neto, J;Booth, M;Munoz, N;Bosch, F X;Meijer, C J;Walboomers, J M
通讯作者：
Walboomers, J M
影响因子：
5.1
作者：
MOSCICKI, AB;WINKLER, B;SCHACHTER, J
通讯作者：
SCHACHTER, J
影响因子：
4.6
作者：
Marzi, M;Vigano, A;Clerici, M
通讯作者：
Clerici, M
影响因子：
9.4
作者：
JACOBS, MV;HUSMAN, AMD;WALBOOMERS, JMM
通讯作者：
WALBOOMERS, JMM