Development and Validation of Prognostic Models for Oral Squamous Cell Carcinoma: A Systematic Review and Appraisal of the Literature.
Development and Validation of Prognostic Models for Oral Squamous Cell Carcinoma: A Systematic Review and Appraisal of the Literature.
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DOI：
10.3390/cancers13225755
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发表时间：
2021-11-17
期刊：
影响因子：
5.2
通讯作者：
Troiano G
中科院分区：
文献类型：
--
作者：
Russo D;Mariani P;Caponio VCA;Lo Russo L;Fiorillo L;Zhurakivska K;Lo Muzio L;Laino L;Troiano G
为了将个性化方法转化为实践，需要选择正确治疗方案的预后模型。这些模型均未进入口腔鳞状细胞癌（OSCC）的临床实践。在这篇文章中，我们进行了系统的审查和后续的质量评估已经发展的预后模型的OSCC的目的是评估其可能的临床应用的情况。(1)背景资料：准确预测口腔鳞状细胞癌（OSCC）患者的癌症生存率对于咨询、治疗计划、随访和术后风险评估非常重要。临床预后模型和列线图的发展越来越受到关注，列线图是它们的图形表示。本研究旨在通过对口腔鳞癌的内部验证来修正临床病理预后模型的预后性能。(2)研究方法：本系统性综述根据科克伦诊断试验准确性综述手册中关于检索的章节、PRISMA（系统性综述和荟萃分析的首选报告项目）指南和预测建模研究系统性综述的关键评价和数据提取（CHARMS）进行。(3)结果：确定了6项评价OSCC患者总生存率的研究。所有研究都进行了内部验证，只有四个模型进行了外部验证。(4)结论：根据本系统性综述的结果，可以声明有必要进行内部验证和收缩，以纠正过度拟合并提供足够的乐观性能。此外，应始终检查连续预测因子的校准、鉴别和非线性。为了降低偏倚的风险，所使用的研究设计应该是前瞻性的，并且应该始终应用插补技术来处理缺失数据。此外，必须报告预后模型的完整方程，以便在新的背景下进行更新和外部验证，并随后评估对健康结果和护理成本效益的影响。
Prognostic models to choose the right treatment schedule are needed in order to translate into practice a personalized approach. None of these models have been still entered into the clinical practice for what concern oral squamous cell carcinoma (OSCC). In this manuscript we performed a systematic review and subsequent quality assessment of already development prognostic model for OSCC with the aim to take stock of the situation on their possible clinical use. (1) Background: An accurate prediction of cancer survival is very important for counseling, treatment planning, follow-up, and postoperative risk assessment in patients with Oral Squamous Cell Carcinoma (OSCC). There has been an increased interest in the development of clinical prognostic models and nomograms which are their graphic representation. The study aimed to revise the prognostic performance of clinical-pathological prognostic models with internal validation for OSCC. (2) Methods: This systematic review was performed according to the Cochrane Handbook for Diagnostic Test Accuracy Reviews chapter on searching, the PRISMA (Preferred Reporting Items for Systematic Reviews and Meta-Analysis) guidelines, and the Critical Appraisal and Data Extraction for Systematic Reviews of Prediction Modelling Studies (CHARMS). (3) Results: Six studies evaluating overall survival in patients with OSCC were identified. All studies performed internal validation, while only four models were externally validated. (4) Conclusions: Based on the results of this systematic review, it is possible to state that it is necessary to carry out internal validation and shrinkage to correct overfitting and provide an adequate performance for optimism. Moreover, calibration, discrimination and nonlinearity of continuous predictors should always be examined. To reduce the risk of bias the study design used should be prospective and imputation techniques should always be applied to handle missing data. In addition, the complete equation of the prognostic model must be reported to allow updating, external validation in a new context and the subsequent evaluation of the impact on health outcomes and on the cost-effectiveness of care.
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影响因子：
4
作者：
Kundu S;Mazumdar M;Ferket B
通讯作者：
Ferket B
DOI：
10.1136/bmj.b2535
发表时间：
2009-07-21
期刊：
BMJ (Clinical research ed.)
影响因子：
--
作者：
Moher D;Liberati A;Tetzlaff J;Altman DG;PRISMA Group
通讯作者：
PRISMA Group
影响因子：
3.9
作者：
Chang B;He W;Ouyang H;Peng J;Shen L;Wang A;Wu P
通讯作者：
Wu P
生存分析第二部分：多元数据分析 - 概念和方法简介。
影响因子：
8.8
作者：
通讯作者：
--
影响因子：
7.2
作者：
Collins, Gary S.;Reitsma, Johannes B.;Moons, Karel G. M.
通讯作者：
Moons, Karel G. M.