Ferroxidase-like and antibacterial activity of PtCu alloy nanoparticles
Ferroxidase-like and antibacterial activity of PtCu alloy nanoparticles
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PtCu合金纳米颗粒的类铁氧化酶和抗菌活性
DOI：
10.1080/10590501.2019.1602991
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发表时间：
2019-04
期刊：
影响因子：
--
通讯作者：
Jun-Jie Yin
中科院分区：
文献类型：
--
作者：
Xiaowei Zhang;Xiumei Jiang;Timothy R. Croley;Mary D. Boudreau;Weiwei He;Junhui Cai;Peirui Li;Jun-Jie Yin
据报道，许多金属纳米颗粒具有固有的类似酶的活性，在化学和生物医学领域具有广阔的应用前景。在这项工作中，我们报道了通过水热处理Cu2+和Pt2+在水溶液中合成的具有亚铁氧酶和过氧化物酶活性的PtCu合金纳米颗粒。用电子自旋共振(ESR)谱和比色法研究发现，PtCuNPs在弱酸性环境中表现出很强的类铁氧酶活性，并且这种活性不受温度或除银离子以外的许多其他离子的影响。基于水杨酸与Fe3+的显色反应，将PtCuNPs的类铁氧酶活性应用于普血口服液中Fe2+的特异性检测。此外，还发现PtCuNPs能够催化过氧化氢并产生羟基自由基，表现出类似过氧化物酶的活性。这有助于理解PtCuNPs对金黄色葡萄球菌和大肠杆菌的潜在抗菌机制。我们的研究证明，PtCuNPs的铁氧酶和类过氧化物酶活性对于Fe2+的检测和抗菌应用是方便和有效的。
Many metal nanoparticles are reported to have intrinsic enzyme-like activities with great promise for chemical and biomedical applications. In this work, we report PtCu alloy nanoparticles, synthesized through hydrothermal treatment of Cu2+ and Pt2+ in aqueous solutions, with ferroxidase- and peroxidase-like activities. Using electron spin resonance (ESR) spectroscopy and colorimetric method, we found that PtCu NPs exhibit strong ferroxidase-like activity in a weakly acidic environment and the activity is not affected by temperature or many other ions except silver ions. The ferroxidase-like activity of PtCu NPs was then applied for the specific detection of Fe2+ in Puxue oral liquid based on the color reaction of salicylic acid with Fe3+. In addition, PtCu NPs was found to be able to catalyze H2O2 and generate hydroxyl radicals, exhibiting peroxidase-like activity. This helps understand the underlying antibacterial mechanism of PtCu NPs against Staphylococcus aureus and Escherichia coli. Our study prove that the ferroxidase- and peroxidase-like activity of PtCu NPs are convenient and efficient for Fe2+ detection and antibacterial applications.
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影响因子：
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