Cooperative and individualistic functions of the microRNAs in the miR-23a~27a~24-2 cluster and its implication in human diseases.
Cooperative and individualistic functions of the microRNAs in the miR-23a~27a~24-2 cluster and its implication in human diseases.
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DOI：
10.1186/1476-4598-9-232
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发表时间：
2010-09-03
期刊：
影响因子：
37.3
通讯作者：
Saini N
中科院分区：
文献类型：
--
作者：
Chhabra R;Dubey R;Saini N
长度约为19-22个核苷酸的小RNA分子，恰当地称为microRNA，在细胞中执行基因调控的任务。有趣的是，直到90年代初，人们对它们知之甚少，但最终，microRNA已经成为研究领域的前沿。大量的microRNA加上它们中的每一个都靶向大量相关和不相关的基因，使它们成为非常有趣的研究分子。增加miRNA的神秘性的事实是，相同的miRNA可以在两种不同的细胞类型中具有拮抗作用，即在一种细胞类型中; miRNA促进增殖，而在另一种细胞类型中，相同的miRNA抑制增殖。microRNA的另一个值得注意的方面是，它们中的许多存在于集群中。仅在人类中，在已知的721种microRNA中，有247种存在于64个簇中，其miRNA间距离小于5000 bp。这种miRNA簇集的原因还不完全清楚，但由于miRNA簇是进化保守的，因此不能排除它们的重要性。本文综述了miR-23 a ~ 27 a ~24-2基因簇在人类健康和疾病中的功能研究进展，并重点介绍了该基因簇中miRNAs的协同作用。
The small RNA molecules of about 19-22 nucleotides in length, aptly called microRNAs, perform the task of gene regulation in the cell. Interestingly, till the early nineties very little was known about them but eventually, the microRNAs have become forefront in the area of research. The huge number of microRNAs plus each one of them targeting a vast number of related as well as unrelated genes makes them very interesting molecules to study. To add to the mystery of miRNAs is the fact that the same miRNA can have antagonizing role in two different cell types i.e. in one cell type; the miRNA promotes proliferation whereas in another cell type the same miRNA inhibits proliferation. Another remarkable aspect of the microRNAs is that many of them exist in clusters. In humans alone, out of 721 microRNAs known, 247 of them occur in 64 clusters at an inter-miRNA distance of less than 5000bp. The reason for this clustering of miRNAs is not fully understood but since the miRNA clusters are evolutionary conserved, their significance cannot be ruled out. The objective of this review is to summarize the recent progress on the functional characterization of miR-23a~27a~24-2 cluster in humans in relation to various health and diseased conditions and to highlight the cooperative effects of the miRNAs of this cluster.
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影响因子：
64.8
作者：
Baek, Daehyun;Villen, Judit;Shin, Chanseok;Camargo, Fernando D.;Gygi, Steven P.;Bartel, David P.
通讯作者：
Bartel, David P.
影响因子：
13.5
作者：
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通讯作者：
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影响因子：
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通讯作者：
Safe, Stephen
miR-23a-27a-24-2簇的上调诱导人类胚胎肾细胞中的caspase依赖性和非依赖性凋亡。
影响因子：
3.7
作者：
Chhabra R;Adlakha YK;Hariharan M;Scaria V;Saini N
通讯作者：
Saini N
影响因子：
14.9
作者：
Altuvia Y;Landgraf P;Lithwick G;Elefant N;Pfeffer S;Aravin A;Brownstein MJ;Tuschl T;Margalit H
通讯作者：
Margalit H