Efficacy of an environmental enrichment intervention for endometriosis: a pilot study.
Efficacy of an environmental enrichment intervention for endometriosis: a pilot study.
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环境富集干预对子宫内膜异位症的功效：一项试点研究。
DOI：
10.3389/fpsyg.2023.1225790
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发表时间：
2023
影响因子：
3.8
通讯作者：
Flores, Idhaliz
中科院分区：
文献类型：
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作者：
De Hoyos, Grace;Ramos-Sostre, Darlenne;Torres-Reveron, Annelyn;Barros-Cartagena, Barbara;Lopez-Rodriguez, Veronica;Nieves-Vazquez, Cristina;Santiago-Saavedra, Fanny;Appleyard, Caroline B;Castro, Eida M;Flores, Idhaliz
我们以前已经证明，环境富集（EE），一种多模式的心理社会干预，包括增加社会互动，新奇和开放空间，改善疾病表现，焦虑和免疫相关的障碍，在子宫内膜异位症大鼠模型。然而，关于EE干预对这种疼痛性、炎症性慢性疾病患者的影响存在知识缺口。通过一项随机临床试验（RCT），调整和测试EE干预对子宫内膜异位症患者盆腔疼痛、心理健康、感知压力、生活质量和全身炎症的疗效。一个具有生理学、神经科学、心理学和女性健康专业知识的多学科团队适应并实施了一项双臂随机对照试验，将EE干预与等待名单对照组进行比较。每隔一周给患者提供6个EE模块（N = 29）;对照组仅接受教育。在基线、研究结束和干预后3个月收集调查数据和生物标本，以评估疼痛（简明疼痛量表，BPI），糖尿病相关生活质量-QoL（子宫内膜异位症健康状况-30，EHP 30），焦虑（广泛性焦虑症7，GAD 7），抑郁症（抑郁症患者健康问卷8，PHQ 8），疼痛灾难化（疼痛灾难性评分，PCS）、压力（感知压力量表-14，PSS 14）和唾液皮质醇水平（AM，PM）。与等待名单对照组相比，EE干预组的参与者在干预结束时和3个月随访时的GAD-7评分显着降低。与基线相比，3个月随访时抑郁、感知压力和生活质量改善。虽然疼痛水平没有改善，但与焦虑、抑郁、生活质量和疼痛灾难化评分显著相关。该试点RCT显示焦虑和抑郁症状、生活质量和感知压力显著改善，支持丰富的环境作为综合性心理社会干预，可用作子宫内膜异位症疼痛标准治疗的辅助治疗。
We have previously shown that Environmental Enrichment (EE), a multi-modal psychosocial intervention consisting of increased social interaction, novelty, and open spaces, improved disease presentation, anxiety, and immune-related disturbances in the rat model of endometriosis. However, there is a knowledge gap regarding the effects of EE interventions in patients with this painful, inflammatory chronic disease. To adapt and test the efficacy of an EE intervention on pelvic pain, mental health, perceived stress, quality of life, and systemic inflammation in endometriosis patients through a randomized clinical trial (RCT). A multidisciplinary team with expertise in physiology, neuroscience, psychology, and women’s health adapted and implemented a two-arm RCT comparing an EE intervention with a wait-list control group. Six EE modules administered on alternate weeks were provided to patients in the intervention (N = 29); controls received education only. Survey data and biospecimens were collected at baseline, end-of-study, and 3-months post-intervention to assess pain (Brief Pain Inventory, BPI), endometriosis-related quality of life-QoL (Endometriosis Health Profile-30, EHP30), anxiety (Generalized Anxiety Disorder 7, GAD7), depression (Patient Health Questionnaire for Depression 8, PHQ8), pain catastrophizing (Pain Catastrophizing Score, PCS), stress (Perceived Stress Scale-14, PSS14), and saliva cortisol levels (AM, PM). Compared to the wait-list controls, participants in the EE intervention showed significantly decreased GAD-7 scores at the end of the intervention and 3-month follow-up. Depression, perceived stress, and QoL improved at the 3-month follow-up compared to baseline. While pain levels did not improve, they significantly correlated with anxiety, depression, QoL and pain catastrophizing scores. This pilot RCT demonstrated significant improvements in anxiety and depressive symptoms, QoL, and perceived stress, supporting enriched environments as an integrative psychosocial intervention to be used as adjuvant to the standard of care for endometriosis pain.
影响因子：
4.4
作者：
Flores-Ramos, Monica;Yoldi-Negrete, Maria;Guiza-Zayas, Rodrigo;Ramirez-Rodriguez, Gerardo-Bernabe;Montes-Castrejon, Adolfo;Fresan, Ana
通讯作者：
Fresan, Ana