Dynamic changes and prevalence of SARS-CoV-2 IgG/IgM antibodies: Analysis of multiple factors.
Dynamic changes and prevalence of SARS-CoV-2 IgG/IgM antibodies: Analysis of multiple factors.
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SARS-CoV-2 IgG/IgM 抗体的动态变化和流行情况：多因素分析
DOI：
10.1016/j.ijid.2021.04.078
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发表时间：
2021-07
期刊：
影响因子：
--
通讯作者：
Luo J
中科院分区：
文献类型：
--
作者：
Luo C;Liu M;Li Q;Zheng X;Ai W;Gong F;Fan J;Liu S;Wang X;Luo J
研究严重急性呼吸综合征冠状病毒2型(SARS-CoV-2)血清学抗体的动态特征，具有重要的现实意义。观察SARS-CoV-2免疫球蛋白M(IgM)和免疫球蛋白G(Ig G)抗体在发病至210天的动态变化及流行情况。用化学发光免疫分析法检测抗体。平均滴度和免疫球蛋白/免疫球蛋白M阳性率在发病30天内达到高峰，然后开始持续下降。发病后180~210d，血清Ig G和Ig M滴度分别为43.1±27.0AU/m L和4.4±5.2AU/m L，阳性率分别为84.3%和12.0%。进一步的统计分析显示，SARS-CoV-2抗体的动态变化和流行与年龄和疾病严重程度有关，而与性别无关。Ig M和Ig G抗体的动态变化和流行率基本一致。即便如此，IgM抗体的下降速度也更快。结果发现，免疫球蛋白水平为16.33±3.15 AU/ml可能代表一个阈值，可作为警报，因为它可能表明在接下来的30-60天内免疫球蛋白水平将变得不可检测。这些结果提供了有关新冠肺炎的重要信息，并可能与诊断、治疗和疫苗开发相关。
To investigate the dynamic characteristics of serological antibodies against the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), which is of much current significance. The dynamic changes and prevalence of immunoglobulin M (IgM) and immunoglobulin G (IgG) antibodies against SARS-CoV-2 were assessed from the time of symptom onset up to 210 days. Antibodies were detected using a chemiluminescence immunoassay. The average titers and IgG/IgM positivity rates reached a peak within 30 days of symptom onset and then began to decline continuously. Between 180 and 210 days following symptom onset, the titers of IgG and IgM were 43.1 ± 27.0 AU/mL and 4.4 ± 5.2 AU/mL, respectively, while the respective positivity rates were 84.3% and 12.0%. Further statistical analyses revealed that the dynamic changes and prevalence of the SARS-CoV-2 IgG/IgM antibodies were related to age and disease severity, but not to sex. The dynamic changes and the prevalence were similar for both the IgM and the IgG antibodies. Even so, there was a more rapid rate of decline for the IgM antibodies. It was found that an IgG level of 16.33 ± 3.15 AU/mL may represent a threshold value that should act as an alert, as it may indicate that the IgG level will become undetectable within the next 30–60 days. The results provide important information concerning COVID-19 and may be of relevance for diagnosis, treatment, and vaccine development.
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