Persistence of SARS-CoV-2-specific antibodies in COVID-19 patients.
Persistence of SARS-CoV-2-specific antibodies in COVID-19 patients.
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DOI：
10.1016/j.intimp.2020.107271
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发表时间：
2021-01
影响因子：
5.6
通讯作者：
Yang C
中科院分区：
文献类型：
--
作者：
Wang Y;Li J;Li H;Lei P;Shen G;Yang C
为了更好地了解SARS-CoV-2感染后的体液免疫，回顾性调查了114名住院的COVID-19患者，这些患者从症状发作起监测了8周以上的抗体。共445份血清样本通过化学发光免疫分析法进行了评估。病毒特异性IgM抗体阳性率在发病后第2 ~ 8周达80%以上，第12周迅速下降至30%以下。IgG浓度在随后下降之前至少3个月保持高水平。与非重症组相比，重症组患者血清IgM水平在第3 ~ 8周显著升高（P = 0.012），而IgG水平无显著性差异（P = 0.053）。3 ~ 8周血清IgM水平与病毒RNA检测阳性相关（r = 0.201，P = 0.044），白蛋白水平（r =-0.295，P = 0.003），乳酸脱氢酶（LDH）水平（r = 0.292，P = 0.003），碱性磷酸酶（ALP）水平（r = 0.254，P = 0.010），C反应蛋白（CRP）水平（r = 0.281，P = 0.004），血清IgG水平与年龄相关（r = 0.207，P = 0.038）。这一结果提供了深入了解SARS-CoV-2抗体的持续时间以及病毒与宿主系统之间的相互作用。
To better understand humoral immunity following SARS-CoV-2 infection, 114 hospitalised COVID-19 patients with antibody monitored over 8 weeks from symptom onset were retrospectively investigated. A total of 445 serum samples were assessed via chemiluminescence immunoassay. Positive rate of virus-specific IgM reached up to over 80% from the second week to the eighth week after symptom onset, then declined quickly to below 30% in the twelfth week. Concentrations of IgG remained high for at least 3 months before subsequently declining. As compared with the non-severe group, serum IgM level from week 3 to week 8 was significantly higher among the patients with severe clinical symptoms (P = 0.012) but not IgG (P = 0.053). Serum IgM level from week 3 to week 8 was correlated with positive virus RNA test (r = 0.201, P = 0.044), albumin level (r = −0.295, P = 0.003), lactic dehydrogenase (LDH) level (r = 0.292, P = 0.003), alkaline phosphatase (ALP) level (r = 0.254, P = 0.010), C-reactive protein (CRP) level (r = 0.281, P = 0.004) during the same course, while serum IgG level was correlated with age (r = 0.207, P = 0.038). This presented results provide insight into duration of SARS-CoV-2 antibodies and interaction between the virus and host systems.
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影响因子：
11.8
作者：
Wu LP;Wang NC;Chang YH;Tian XY;Na DY;Zhang LY;Zheng L;Lan T;Wang LF;Liang GD
通讯作者：
Liang GD
DOI：
10.1016/j.diagmicrobio.2017.07.006
发表时间：
2017-10
影响因子：
2.9
作者：
Ko JH;Müller MA;Seok H;Park GE;Lee JY;Cho SY;Ha YE;Baek JY;Kim SH;Kang JM;Kim YJ;Jo IJ;Chung CR;Hahn MJ;Drosten C;Kang CI;Chung DR;Song JH;Kang ES;Peck KR
通讯作者：
Peck KR
影响因子：
82.9
作者：
Long, Quan-Xin;Liu, Bai-Zhong;Huang, Ai-Long
通讯作者：
Huang, Ai-Long
影响因子：
9
作者：
Channappanavar R;Perlman S
通讯作者：
Perlman S
DOI：
10.1001/jama.2020.7869
发表时间：
2020-06-09
期刊：
JAMA
影响因子：
--
作者：
Kirkcaldy RD;King BA;Brooks JT
通讯作者：
Brooks JT