Frailty is associated with susceptibility and severity of pneumonia in older adults (A JAGES multilevel cross-sectional study).
Frailty is associated with susceptibility and severity of pneumonia in older adults (A JAGES multilevel cross-sectional study).
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DOI：
10.1038/s41598-021-86854-3
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发表时间：
2021-04-12
影响因子：
4.6
通讯作者：
Kondo K
中科院分区：
文献类型：
--
作者：
Iwai-Saito K;Shobugawa Y;Aida J;Kondo K
肺炎是全世界老年人死亡的主要原因。最近，几项研究报告说，虚弱与因呼吸道传染病（包括肺炎）住院的老年人的死亡率有关。然而，在功能独立的社区居住老年人中，虚弱是否与肺炎的易感性和严重程度相关尚不清楚。在这项研究中，我们研究了虚弱是否会增加老年人对肺炎和住院的易感性。我们使用了日本老年学评估研究的横断面数据;数据是通过使用基于邮件的自我报告问卷从177，991名年龄≥ 65岁的功能独立社区居住老年人中收集的。我们的研究结果表明，在调整协变量后，虚弱与肺炎的发生和住院显著相关;（偏好比{PR} 1.92，95%置信区间{95% CI} [1.66-2.22]和PR 1.80，95% CI [1.42-2.28]，分别为p < 0.001）。虚弱前期仅与肺炎的发生相关。此外，日常生活的工具性活动，体力，营养状况，口腔功能，居家，和抑郁状态在体弱的老年人与肺炎的发生和住院治疗的一个或两个。我们的研究结果表明，虚弱影响老年人对肺炎的易感性和严重性。
Pneumonia is a leading cause of mortality among older adults worldwide. Recently, several studies reported that frailty was associated with mortality among older adults hospitalized due to respiratory infectious diseases, including pneumonia. However, it is unknown whether frailty is associated with susceptibility to and severity of pneumonia in functionally-independent community-dwelling older adults. In this study, we examined whether frailty increased the susceptibility to pneumonia and hospitalization in older adults. We used cross-sectional data from the Japan Gerontological Evaluation Study; the data was collected by using mail-based, self-reported questionnaires from 177,991 functionally-independent community-dwelling older adults aged ≥ 65 years. Our results showed that frailty was significantly associated with both occurrence of and hospitalization due to pneumonia after adjustments with covariates; (Preference ratio {PR} 1.92, 95% confidence interval {95% CI} [1.66–2.22] and PR 1.80, 95% CI [1.42–2.28], respectively, p < 0.001 for the both). Pre-frailty was associated only with the occurrence of pneumonia. Besides, the instrumental activity of daily living, physical strength, nutrition status, oral function, homeboundness, and depression status in frail older adults were associated with either or both occurrence of and hospitalization due to pneumonia. Our results suggest that frailty influenced the susceptibility to and severity of pneumonia in older adults.
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影响因子：
2.9
作者：
Luo J;Tang W;Sun Y;Jiang C
通讯作者：
Jiang C
影响因子：
24.3
作者：
Almirall, Jordi;Rofes, Laia;Clave, Pere
通讯作者：
Clave, Pere
影响因子：
4
作者：
Herr, Marie;Latouche, Aurelien;Ankri, Joel
通讯作者：
Ankri, Joel
DOI：
10.1016/j.rinim.2013.01.001
发表时间：
2013-01-01
期刊：
Results in immunology
影响因子：
--
作者：
Bachi, Andre L L;Suguri, Vinicius M;Lopes, Jose D
通讯作者：
Lopes, Jose D
影响因子：
6.3
作者：
Qiu WQ;Dean M;Liu T;George L;Gann M;Cohen J;Bruce ML
通讯作者：
Bruce ML