Mapping Aerosolized Saliva on Face Coverings for Biosensing Applications.
Mapping Aerosolized Saliva on Face Coverings for Biosensing Applications.
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DOI：
10.1021/acs.analchem.1c02399
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发表时间：
2021-08-10
影响因子：
7.4
通讯作者：
Jokerst JV
中科院分区：
文献类型：
--
作者：
Jin Z;Jorns A;Yim W;Wing R;Mantri Y;Zhou J;Zhou J;Wu Z;Moore C;Penny WF;Jokerst JV
在聚集环境中，口罩可以防止SARS-CoV-2的传播，并有助于控制正在进行的COVID-19全球大流行，因为面部覆盖物可以阻止呼吸道飞沫的传播。虽然许多团体已经研究了面部覆盖物作为个人防护设备，但这些呼吸道飞沫也可以作为诊断液来报告健康状况;令人惊讶的是，从这个角度对面部覆盖物的研究非常有限。在这里，我们确定了在各种面部覆盖物上捕获的雾化唾液的浓度和分布（通过α-淀粉酶水平）。我们的研究结果表明，α-淀粉酶在面部覆盖物上以时间依赖性的方式积累，尽管水平不同，例如，护颈镜和外科口罩捕获的α-淀粉酶比布口罩和N95消毒器多约3倍。此外，唾液气溶胶主要在多层面罩的内层上检测到。我们还发现，唾液滴在面具上的分布与面部覆盖物的形态以及它们与面部曲率的一致性相关。这些发现促使我们扩展这项工作，并构建能够原位检测生物标志物的多功能传感条，以创建“智能”口罩。这项工作强调，面部覆盖物是生物流体收集和比色生物传感的有前途的平台，这对开发空气传播疾病的监测工具是个好兆头。
Facemasks in congregate settings prevent the transmission of SARS-CoV-2 and help control the ongoing COVID-19 global pandemic because face coverings can arrest transmission of respiratory droplets. While many groups have studied face coverings as personal protective equipment, these respiratory droplets can also serve as a diagnostic fluid to report on health state; surprisingly, studies of face coverings from this perspective are quite limited. Here, we determined the concentration and distribution of aerosolized saliva (via α-amylase levels) captured on various face coverings. Our results showed that α-amylase accumulated on face coverings in a time-dependent way albeit at different levels, e.g., neck gaiters and surgical masks captured about 3-fold more α-amylase than cloth masks and N95 respirators. In addition, the saliva aerosols were primarily detected on the inner layer of multilayered face coverings. We also found that the distribution of salivary droplets on the mask correlated with the morphologies of face coverings as well as their coherence to the face curvature. These findings motivated us to extend this work and build multifunctional sensing strips capable of detecting biomarkers in situ to create “smart” masks. The work highlights that face coverings are promising platforms for biofluid collection and colorimetric biosensing, which bode well for developing surveillance tools for airborne diseases.
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DOI：
10.1080/02786826.2020.1862409
发表时间：
2021-01-07
期刊：
Aerosol science and technology : the journal of the American Association for Aerosol Research
影响因子：
--
作者：
通讯作者：
--
影响因子：
--
作者：
Malamud D
通讯作者：
Malamud D
DOI：
10.1002/hed.26232
发表时间：
2020-05-08
影响因子：
2.9
作者：
See, Anna;Toh, Song Tar
通讯作者：
Toh, Song Tar
基于表面增强拉曼散射传感器的呼吸分析可区分早期和晚期胃癌患者与健康人。
影响因子：
17.1
作者：
Chen, Yunsheng;Zhang, Yixia;Cui, Daxiang
通讯作者：
Cui, Daxiang
影响因子：
17.1
作者：
Konda, Abhiteja;Prakash, Abhinav;Guha, Supratik
通讯作者：
Guha, Supratik