Carcinogenesis in the biliary system associated with APDJ.
Carcinogenesis in the biliary system associated with APDJ.
复制标题
与 APDJ 相关的胆道系统癌发生。
DOI：
10.1007/s005340050110
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发表时间：
1999
期刊：
影响因子：
--
通讯作者：
Miin
中科院分区：
文献类型：
--
作者：
T. Chao;T. Chao;Chia‐Siu Wang;Chia‐Siu Wang;Y. Jan;Y. Jan;H. Chen;H. Chen;Miin;Miin
胰胆管结异常（APDJ）是一种罕见的先天性异常，被认为是胆道癌发展的病因之一。目前普遍认为APDJ引起的胰液反流进入胆道是胆道癌的病因之一。胰液反流导致胆汁改变，引起慢性炎症和细胞增殖增加，导致胆道上皮增生、化生和胆道癌。与没有APDJ的胆道癌相比，与APDJ相关的胆道癌中K-ras突变更为普遍。与APDJ相关的胆道癌和与APDJ无关的胆道癌中p53的过表达没有差异。需要进一步的研究来评估细胞因子和生长因子在胆道系统APDJ相关癌变中的作用。
Anomalous pancreaticobiliary ductal junction (APDJ) is a rare congenital anomaly which is considered to be an etiological factor in the development of carcinoma of the biliary tract. It is generally accepted that pancreatic juice reflux into the biliary tract due to APDJ is one of the etiologies of biliary tract cancers. Refluxing pancreatic juice results in changes of bile and induces chronic inflammation and increased cellular proliferation, leading to epithelial hyperplasia, metaplasia, and carcinoma of the biliary tract. K-ras mutations are more prevalent in the carcinomas of biliary tract associated with APDJ compared with those without APDJ. There is no difference in the overexpression of p53 between biliary tract carcinomas associated with APDJ and those unassociated with APDJ. Further studies are needed to evaluate the role of cytokines and growth factors in carcinogenesis of the biliary system associated with APDJ.
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影响因子：
11.2
作者：
I. Wistuba;K. Sugio;J. Hung;Y. Kishimoto;A. Virmani;I. Roá;J. Albores–Saavedra;A. Gazdar
通讯作者：
I. Wistuba;K. Sugio;J. Hung;Y. Kishimoto;A. Virmani;I. Roá;J. Albores–Saavedra;A. Gazdar
影响因子：
11.2
作者：
Joyce Bos
通讯作者：
Joyce Bos
影响因子：
11.2
作者：
D. Billadeau;D. Jelinek;N. Shah;T. Lebien;B. V. Van Ness
通讯作者：
D. Billadeau;D. Jelinek;N. Shah;T. Lebien;B. V. Van Ness
影响因子：
56.9
作者：
HOLLSTEIN, M;SIDRANSKY, D;HARRIS, CC
通讯作者：
HARRIS, CC