Dietary lignans: physiology and potential for cardiovascular disease risk reduction.
Dietary lignans: physiology and potential for cardiovascular disease risk reduction.
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DOI：
10.1111/j.1753-4887.2010.00319.x
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发表时间：
2010-10
影响因子：
6.1
通讯作者：
McCullough ML
中科院分区：
文献类型：
--
作者：
Peterson J;Dwyer J;Adlercreutz H;Scalbert A;Jacques P;McCullough ML
我们回顾了木脂素生理学、木脂素干预和流行病学研究，以确定它们是否降低了西方人群患心血管疾病的风险。五项使用亚麻籽木脂素补充剂的干预研究表明，它与 C 反应蛋白有益，而包含这些研究的荟萃分析也表明，它对血浆总胆固醇和低密度脂蛋白胆固醇有降低作用。三项使用芝麻素补充剂的干预研究表明可能与降低血脂和血压有关。十一项人类观察性流行病学研究考察了木酚素的膳食摄入量与心血管疾病风险的关系。其中五项研究表明，增加木脂素膳食摄入量或增加血清肠内酯（一种用作木脂素摄入生物标志物的肠木脂素）水平可降低风险，五项研究具有临界意义，一项研究无效。木脂素与降低心血管疾病风险之间的关联是有前景的，但尚未得到充分证实，这可能是由于西方习惯饮食中木脂素摄入量较低。在干预研究中使用较高剂量时，相关性更加明显。
We reviewed lignan physiology and lignan intervention and epidemiological studies to determine if they decreased the risks of cardiovascular disease in Western populations. Five intervention studies using flaxseed lignan supplements indicated beneficial associations with C-reactive protein and a meta-analysis, which included these studies, also suggested a lowering effect on plasma total and low-density lipoprotein cholesterol. Three intervention studies using sesamin supplements indicated possible lipid and blood pressure lowering associations. Eleven human observational epidemiological studies examined dietary intakes of lignans in relation to cardiovascular disease risk. Five showed decreased risk with either increasing dietary intakes of lignans or increased levels of serum enterolactone (an enterolignan used as a biomarker of lignan intake), five studies were of borderline significance, and one was null. The associations between lignans and decreased risk of cardiovascular disease are promising, but are yet not well established, perhaps due to low lignan intakes in habitual Western diets. At the higher doses used in intervention studies, associations were more evident.
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影响因子：
7.7
作者：
Alonso, Alvaro;Jose Beunza, Juan;Martinez-Gonzalez, Miguel Angel
通讯作者：
Martinez-Gonzalez, Miguel Angel
影响因子：
5.1
作者：
Aller, R;de Luis, DA;Hernandez, JMG
通讯作者：
Hernandez, JMG
影响因子：
4.4
作者：
Clavel, T;Henderson, G;Blaut, M
通讯作者：
Blaut, M
影响因子：
4.2
作者：
Begum, AN;Nicolle, C;Scalbert, A
通讯作者：
Scalbert, A
DOI：
10.1016/0960-0760(92)90359-q
发表时间：
1992-03-01
影响因子：
4.1
作者：
ADLERCREUTZ, H;MOUSAVI, Y;HASE, T
通讯作者：
HASE, T