Association between TLR4 (+896A/G and +1196C/T) polymorphisms and gastric cancer risk: an updated meta-analysis.
Association between TLR4 (+896A/G and +1196C/T) polymorphisms and gastric cancer risk: an updated meta-analysis.
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DOI：
10.1371/journal.pone.0109605
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发表时间：
2014
期刊：
影响因子：
3.7
通讯作者：
Su L
中科院分区：
文献类型：
--
作者：
Zhou Q;Wang C;Wang X;Wu X;Zhu Z;Liu B;Su L
Toll样受体4（TLR 4）是胃上皮细胞内脂多糖信号转导的受体。它在天然免疫激活和病原体识别中起着关键作用，因此在胃癌的发生和发展中起着调节作用。越来越多的研究探讨了TLR 4基因多态性与胃癌易感性的关系，但结果仍存在争议和矛盾。为研究TLR 4基因+896A/G和+1196C/T多态性对胃癌的影响，我们进行了一项荟萃分析。我们进行了一项全面的检索，以确定所有合格的病例对照出版物，研究TLR 4多态性与胃癌风险之间的关联。使用比值比（OR）和相应的95%置信区间（CI）来评估这种关联。截至2014年3月26日，PubMed和EMBase共检索到10篇已发表的病例对照研究，共涉及1888例胃癌患者和3433例对照受试者。在总体荟萃分析中，在TLR 4 + 896 A/G多态性（杂合模型，AG vs. AA：OR = 1.67，95% CI，1.39-2.01;加性模型，G vs. A：OR = 1.64，95% CI，1.37-1.95）和TLR 4 + 1196 C/T多态性（杂合模型，CT vs. CC：OR= 1.42，95% CI，1.11-1.81;加性模型，T vs. C：OR = 1.36，95% CI，1.08-1.72）中检测到胃癌风险显著增加，在高加索人的亚组分析中获得了相似的结果，而在非高加索人的任何遗传模型中均未检测到相关性。 总体结果表明，TLR 4多态性（+896 A/G和+1196 C/T）可能与高加索人胃癌风险显著增加相关。
Toll-like receptor 4 (TLR4) is a receptor of lipopolysaccharide in the signaling transduction of gastric epithelial cell. It plays a pivotal role in activation of innate immunity and pathogen recognition and thus acts as a modulator in the development and progression of gastric cancer. Growing studies explored the association of polymorphisms in TLR4 with susceptibility to gastric cancer, but the results have remained controversial and conflicting. To investigate the effect of two selected TLR4 (+896A/G and +1196C/T) polymorphisms on gastric cancer, we performed a meta-analysis. A comprehensive search was conducted to identify all eligible case-control publications investigating the association between TLR4 polymorphisms and gastric cancer risk. Odds ratios (OR) and corresponding 95% confidence intervals (CI) were used to assess such association. Up to March 26 2014, 10 published case-control studies from PubMed and EMBase were available, involving a total of 1888 gastric cancer patients and 3433 control subjects. In the overall meta-analyses, a significantly increased gastric cancer risk was detected in TLR4 +896A/G polymorphism (heterozygous model, AG vs. AA: OR = 1.67, 95% CI, 1.39–2.01; additive model, G vs. A: OR = 1.64, 95% CI, 1.37–1.95) and TLR4 +1196C/T polymorphism (heterozygous model, CT vs. CC: OR = 1.42, 95% CI, 1.11–1.81; additive model, T vs. C: OR = 1.36, 95% CI, 1.08–1.72), similar results were obtained in the subgroup analyses of Caucasian, whereas no associations were detected in any genetic models of non-Caucasian. The overall results suggest that TLR4 polymorphisms (+896A/G and +1196C/T) may be associated with a significantly increased gastric cancer risk in Caucasian.
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影响因子：
3.8
作者：
Garza-Gonzalez E;Bosques-Padilla FJ;Mendoza-Ibarra SI;Flores-Gutierrez JP;Maldonado-Garza HJ;Perez-Perez GI
通讯作者：
Perez-Perez GI
影响因子：
2.9
作者：
da Costa, Bruno R.;Cevallos, Myriam;Egger, Matthias
通讯作者：
Egger, Matthias
影响因子：
5.7
作者：
Ferwerda, Bart;McCall, Matthew B. B.;Netea, Mihai G.
通讯作者：
Netea, Mihai G.
影响因子：
11.2
作者：
Huang, B;Zhao, J;Xiong, HB
通讯作者：
Xiong, HB
影响因子：
3.1
作者：
Kato, Ikuko;Canzian, Federico;Munoz, Nubia
通讯作者：
Munoz, Nubia