Newborn mice vaccination with BCG.HIVA²²² + MVA.HIVA enhances HIV-1-specific immune responses: influence of age and immunization routes.
Newborn mice vaccination with BCG.HIVA²²² + MVA.HIVA enhances HIV-1-specific immune responses: influence of age and immunization routes.
复制标题
DOI：
10.1155/2011/516219
复制
发表时间：
2011
影响因子：
--
通讯作者：
Joseph J
中科院分区：
文献类型：
--
作者：
Saubi N;Im EJ;Fernández-Lloris R;Gil O;Cardona PJ;Gatell JM;Hanke T;Joseph J
我们评估了年龄和免疫途径对新生儿（7日龄）和成年（7周龄）BALB/c小鼠接种卡介苗后诱导HIV-1和结核分枝杆菌特异性免疫应答的影响。HIVA222撇和MVA。HIVA提振。在脾细胞中分析特异性HIV-1细胞免疫应答。每周记录新生小鼠的体重。在皮内接种的成年小鼠中，产生IFN-γ的hiv特异性CD8+ T细胞的频率较高，而在皮下接种的成年和新生小鼠中，产生IFN-γ的频率较低。在所有情况下，当小鼠接种BCG时，IFN-γ的产生都显著增加。HIVA222与BCGwt比较。当评估hiv特异性CTL活性时，新生小鼠的特异性杀伤频率高于成年小鼠。包括卡介苗在内的初级强化疫苗接种方案。HIVA222和MVA。在新生小鼠中接种HIVA是安全的。BCG的管理。HIVA222对新生小鼠是安全的和免疫原性的，并增加了MVA诱导的hiv特异性反应。HIVA疫苗。这可能是婴儿艾滋病和结核病二价疫苗的一个很好的模型。
We have evaluated the influence of age and immunization routes for induction of HIV-1- and M. tuberculosis-specific immune responses after neonatal (7 days old) and adult (7 weeks old) BALB/c mice immunization with BCG.HIVA222 prime and MVA.HIVA boost. The specific HIV-1 cellular immune responses were analyzed in spleen cells. The body weight of the newborn mice was weekly recorded. The frequencies of HIV-specific CD8+ T cells producing IFN-γ were higher in adult mice vaccinated intradermally and lower in adult and newborn mice vaccinated subcutaneously. In all cases the IFN-γ production was significantly higher when mice were primed with BCG.HIVA222 compared with BCGwt. When the HIV-specific CTL activity was assessed, the frequencies of specific killing were higher in newborn mice than in adults. The prime-boost vaccination regimen which includes BCG.HIVA222 and MVA.HIVA was safe when inoculated to newborn mice. The administration of BCG.HIVA222 to newborn mice is safe and immunogenic and increased the HIV-specific responses induced by MVA.HIVA vaccine. It might be a good model for infant HIV and Tuberculosis bivalent vaccine.
登录
查看更多内容
DOI：
10.1099/00221287-142-4-915
发表时间：
1996-04-01
期刊：
MICROBIOLOGY-UK
影响因子：
--
作者：
Andersson, SGE;Sharp, PM
通讯作者：
Sharp, PM
影响因子：
1.5
作者：
Lagranderie, M;Winter, N;Gheorghiu, M
通讯作者：
Gheorghiu, M
影响因子：
5.4
作者：
Ami, Y;Izumi, Y;Honda, M
通讯作者：
Honda, M
DOI：
10.1073/pnas.92.23.10693
发表时间：
1995-11-07
影响因子：
11.1
作者：
HONDA, M;MATSUO, K;YAMAZAKI, S
通讯作者：
YAMAZAKI, S
影响因子：
--
作者：
Joseph, Joan;Fernandez-Lloris, Raquel;Maria Gatell, Josep
通讯作者：
Maria Gatell, Josep