Three Dimensional Lower Extremity Musculoskeletal Geometry of the Visible Human Female and Male.
Three Dimensional Lower Extremity Musculoskeletal Geometry of the Visible Human Female and Male.
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DOI：
10.1038/s41597-022-01905-2
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发表时间：
2023-01-18
期刊：
影响因子：
9.8
通讯作者：
Shelburne, Kevin B.
中科院分区：
文献类型：
--
作者：
Andreassen, Thor E.;Hume, Donald R.;Hamilton, Landon D.;Walker, Karen E.;Higinbotham, Sean E.;Shelburne, Kevin B.
人体功能的模型和模拟影响着医学和医疗技术。特别是，肌肉骨骼模型为深入了解人体提供了一条途径，这可能是不可能的。然而，由于缺乏可自由获取的解剖模型和几何数据集，实现功能性多尺度人体模型的最终目标已经放缓。此外，由于普遍强调男性几何，女性特有的几何被忽视了。为了帮助实现这一目标，我们开发并分享了从国家医学图书馆中提取的完整的三维肌肉骨骼几何形状，这些几何形状取自可见的人类女性和男性冷冻切片。从骨盆到脚踝的肌肉、骨骼、软骨、韧带和脂肪被数字化并输出。这些几何图形为高保真可变形组织的人体肌肉骨骼模拟的持续工作提供了基础，使人们能够更好地理解正常功能和评估病理和治疗。这项工作是新颖的，因为它包括男性和女性可见人类标本，在多个层次的后处理输出，以最大限度地重复使用数据，并且是公开的。
Models and simulations of human function impact medicine and medical technology. Particularly, musculoskeletal modeling provides an avenue for insight into the human body, which might not be otherwise possible. However, reaching the ultimate goal of functional multi-scale human models has been slowed by the lack of freely available datasets of anatomical models and geometries. Moreover, female-specific geometries have been neglected with a widespread emphasis on male geometry. To help realize this goal, we have developed and shared complete three-dimensional musculoskeletal geometries extracted from the National Libraries of Medicine Visible Human Female and Male cryosections. Muscle, bone, cartilage, ligament, and fat from the pelvis to the ankle were digitized and exported. These geometries provide a foundation for continued work in human musculoskeletal simulation with high-fidelity deformable tissues that enable a better understanding of normal function and the evaluation of pathologies and treatments. This work is novel as it includes both the male and female Visible Human specimens, outputs at multiple levels of post-processing for maximum data reuse, and is publicly available.
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影响因子：
2
作者：
Iwamoto, Masami;Nakahira, Yuko;Kimpara, Hideyuki
通讯作者：
Kimpara, Hideyuki
影响因子：
2.5
作者：
Fedorov, Andriy;Beichel, Reinhard;Kalpathy-Cramer, Jayashree;Finet, Julien;Fillion-Robin, Jean-Christophe;Pujol, Sonia;Bauer, Christian;Jennings, Dominique;Fennessy, Fiona;Sonka, Milan;Buatti, John;Aylward, Stephen;Miller, James V.;Pieper, Steve;Kikinis, Ron
通讯作者：
Kikinis, Ron
DOI：
10.1146/annurev-bioeng-071516-044738
发表时间：
2017-06-21
影响因子：
9.7
作者：
Maas SA;Ateshian GA;Weiss JA
通讯作者：
Weiss JA
影响因子：
4.6
作者：
Delp, Scott L.;Anderson, Frank C.;Thelen, Darryl G.
通讯作者：
Thelen, Darryl G.
影响因子：
2.4
作者：
Jastrow, H;Vollrath, L
通讯作者：
Vollrath, L