The posttranslational processing of ras p21 is critical for its stimulation of yeast adenylate cyclase
The posttranslational processing of ras p21 is critical for its stimulation of yeast adenylate cyclase
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ras p21 的翻译后加工对于刺激酵母腺苷酸环化酶至关重要
DOI：
10.1128/mcb.12.10.4515-4520.1992
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发表时间：
1992
影响因子：
5.3
通讯作者：
Y. Takai
中科院分区：
文献类型：
--
作者：
H. Horiuchi;K. Kaibuchi;M. Kawamura;Y. Matsuura;N. Suzuki;Yuichi Kuroda;T. Kataoka;Y. Takai
Mammalian ras genes substitute for the yeast RAS gene, and their products activate adenylate cyclase in yeast cells, although the direct target protein of mammalian ras p21s remains to be identified. ras p21s undergo posttranslational processing, including prenylation, proteolysis, methylation, and palmitoylation, at their C-terminal regions. We have previously reported that the posttranslational processing of Ki-ras p21 is essential for its interaction with one of its GDP/GTP exchange proteins named smg GDS. In this investigation, we have studied whether the posttranslational processing of Ki- and Ha-ras p21s is critical for their stimulation of yeast adenylate cyclase in a cell-free system. We show that the posttranslationally fully processed Ki- and Ha-ras p21s activate yeast adenylate cyclase far more effectively than do the unprocessed proteins. The previous and present results suggest that the posttranslational processing of ras p21s is important for their interaction not only with smg GDS but also with the target protein.
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影响因子：
56.9
作者：
L. C. Robinson;J. Gibbs;M. Marshall;I. Sigal;K. Tatchell
通讯作者：
L. C. Robinson;J. Gibbs;M. Marshall;I. Sigal;K. Tatchell
影响因子：
16.6
作者：
M. Barbacid
通讯作者：
M. Barbacid
DOI：
10.1073/pnas.87.8.3042
发表时间：
1990-04-01
影响因子：
11.1
作者：
JACKSON, JH;COCHRANE, CG;DER, CJ
通讯作者：
DER, CJ
能够刺激ras蛋白鸟嘌呤核苷酸交换反应的因子的纯化及其对ras相关小分子质量G蛋白的影响。
DOI：
10.1073/pnas.87.20.8008
发表时间：
1990
影响因子：
11.1
作者：
Huang,YK;Kung,HF;Kamata,T
通讯作者：
Kamata,T
酵母腺苷酸环化酶与 RAS 蛋白相互作用需要富含亮氨酸的重复序列和羧基末端。
DOI：
10.1073/pnas.87.22.8711
发表时间：
1990
影响因子：
11.1
作者：
Suzuki,N;Choe,HR;Nishida,Y;Yamawaki-Kataoka,Y;Ohnishi,S;Tamaoki,T;Kataoka,T
通讯作者：
Kataoka,T