Targeting Dermal Fibroblast Subtypes in Antifibrotic Therapy: Surface Marker as a Cellular Identity or a Functional Entity?
Targeting Dermal Fibroblast Subtypes in Antifibrotic Therapy: Surface Marker as a Cellular Identity or a Functional Entity?
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抗纤维化治疗中针对真皮成纤维细胞亚型：表面标记作为细胞身份还是功能实体？
DOI：
10.3389/fphys.2021.694605
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发表时间：
2021
影响因子：
4
通讯作者：
Zan T
中科院分区：
文献类型：
--
作者：
Huang X;Khoong Y;Han C;Su D;Ma H;Gu S;Li Q;Zan T
成纤维细胞是纤维化疾病中的主要效应细胞，并且已被发现具有高度异质性。最近，人类皮肤中的成纤维细胞异质性已得到广泛研究，并且已经确定了几种真皮成纤维细胞亚型的表面标志物，这为未来的抗纤维化治疗带来了希望。然而，表面标志物应仅仅被视为谱系标志还是成纤维细胞亚型的功能实体仍有待确认，这可能会使对这些成纤维细胞亚型细胞功能的解释更加复杂。本综述旨在提供有关皮肤以及其他器官系统纤维化疾病中成纤维细胞表面标志物的当前证据的最新情况。具体而言，将表面标志物作为谱系标志物以及作为功能性膜蛋白进行操作的研究都进行了平行评估，希望从多个角度揭示由多种成纤维细胞亚型导致的组织纤维化发病机制背后的潜在机制，为未来的转化研究提供启示。
Fibroblasts are the chief effector cells in fibrotic diseases and have been discovered to be highly heterogeneous. Recently, fibroblast heterogeneity in human skin has been studied extensively and several surface markers for dermal fibroblast subtypes have been identified, holding promise for future antifibrotic therapies. However, it has yet to be confirmed whether surface markers should be looked upon as merely lineage landmarks or as functional entities of fibroblast subtypes, which may further complicate the interpretation of cellular function of these fibroblast subtypes. This review aims to provide an update on current evidence on fibroblast surface markers in fibrotic disorders of skin as well as of other organ systems. Specifically, studies where surface markers were treated as lineage markers and manipulated as functional membrane proteins are both evaluated in parallel, hoping to reveal the underlying mechanism behind the pathogenesis of tissue fibrosis contributed by various fibroblast subtypes from multiple angles, shedding lights on future translational researches.
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影响因子：
--
作者：
Chen WC;Chang YS;Hsu HP;Yen MC;Huang HL;Cho CY;Wang CY;Weng TY;Lai PT;Chen CS;Lin YJ;Lai MD
通讯作者：
Lai MD
影响因子：
64.8
作者：
通讯作者：
--
影响因子：
10.8
作者：
Bessi, Valrie L.;Labbe, Sebastien M.;Marleau, Sylvie
通讯作者：
Marleau, Sylvie
影响因子：
7.7
作者：
Aroor AR;Habibi J;Ford DA;Nistala R;Lastra G;Manrique C;Dunham MM;Ford KD;Thyfault JP;Parks EJ;Sowers JR;Rector RS
通讯作者：
Rector RS
影响因子：
15.9
作者：
Febbraio, M;Hajjar, DP;Silverstein, RL
通讯作者：
Silverstein, RL