Immunohistochemical analysis of gynecologic tumors.
Immunohistochemical analysis of gynecologic tumors.
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妇科肿瘤的免疫组织化学分析。
DOI：
--
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发表时间：
2001
影响因子：
2.4
通讯作者：
A. Gown
中科院分区：
文献类型：
--
作者：
H. Yaziji;A. Gown
免疫组织化学 (IHC) 等辅助技术使外科病理学家能够从固定的脱石蜡组织标本中提取更多信息，并提供对患者最佳临床管理至关重要的数据。在这篇关于 IHC 在妇科恶性肿瘤分析中的应用的综述中，总结了免疫组织化学分析对宫颈、子宫内膜和卵巢肿瘤的有用性。在子宫颈中，发育不良与 Ki-67 抗原表达的定性和定量改变以及检测人乳头瘤病毒的能力相关。子宫内膜子宫内膜样腺癌表现出高度特征性的免疫表型，细胞角蛋白和波形蛋白共表达，并显示高分子量细胞角蛋白表达灶；此外，对雌激素和孕激素受体以及 p53 表达进行 IHC 分析可以提供有关该肿瘤的重要预后信息。子宫内膜间质瘤可能表现出部分平滑肌免疫表型，但 CD10 等新型标记物为识别这些肿瘤提供了新工具。正常卵巢表面上皮 (OSE) 和相应肿瘤的免疫表型与间皮有显着重叠，但也有重要区别，并且重要的新标记物（如 Wilms 肿瘤基因产物）可用于识别 OSE 癌。 OSE 癌的重要预后标志物包括 HER-2/neu 基因产物和 p53，其变化均可通过 IHC 技术进行评估。最后，最近出现的卵巢间质标记物，包括 Melan-A 和抑制素-α，为阳性鉴定卵巢间质瘤提供了一种方法，这种肿瘤可以表现出千变万化的组织学外观。
Ancillary techniques such as immunohistochemistry (IHC) enable the surgical pathologist to extract additional information from fixed, deparaffinized tissue specimens and to provide data critical to optimal clinical management of the patient. In this review of applications of IHC to the analysis of gynecologic malignancies, the usefulness of immunohistochemical analysis of neoplasms of the cervix, endometrium, and ovary is summarized. In the uterine cervix, dysplasia is associated with qualitative and quantitative alterations in the expression of the Ki-67 antigen expression, as well as an ability to detect human papillomavirus. Endometrial endometrioid adenocarcinomas display a highly characteristic immunophenotype, with coexpression of cytokeratin and vimentin and demonstration of foci of high molecular weight cytokeratin expression; in addition, IHC analysis of estrogen and progesterone receptor and p53 expression can provide important prognostic information about this tumor. Stromal tumors of the endometrium may display a partial smooth muscle immunophenotype, but novel markers such as CD10 provide new tools for the identification of these tumors. The immunophenotypes of the normal ovarian surface epithelium (OSE) and corresponding tumors display significant overlap with, but important distinctions from, mesothelium, and important new markers such as the Wilms tumor gene product can prove useful in the identification of carcinomas of the OSE. Important prognostic markers for carcinomas of the OSE include the HER-2/neu gene product and p53, alterations of which can both be assessed by IHC techniques. Finally, the recent availability of markers of ovarian stroma, including Melan-A and inhibin-alpha, has provided a means for the positive identification of ovarian stromal tumors, which can manifest protean histological appearances.
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影响因子：
11.2
作者：
V. Masciullo;A. Sgambato;C. Pacilio;B. Pucci;G. Ferrandina;J. Palazzo;A. Carbone;A. Cittadini;S. Mancuso;G. Scambia;A. Giordano
通讯作者：
V. Masciullo;A. Sgambato;C. Pacilio;B. Pucci;G. Ferrandina;J. Palazzo;A. Carbone;A. Cittadini;S. Mancuso;G. Scambia;A. Giordano
影响因子：
11.2
作者：
A. Berchuck;R. Whitaker;G. Olt;J. Soper;D. Clarke‐Pearson;A. Kamel;A. Kamel;R. Bast;B. Kerns;R. Kinney;R. Dodge;P. Marks;S. McKenzie;S. Yin
通讯作者：
A. Berchuck;R. Whitaker;G. Olt;J. Soper;D. Clarke‐Pearson;A. Kamel;A. Kamel;R. Bast;B. Kerns;R. Kinney;R. Dodge;P. Marks;S. McKenzie;S. Yin
DOI：
--
发表时间：
1992
期刊：
The American journal of pathology
影响因子：
--
作者：
P. Porter;A. Gown;Steven G. Kramp;M. Coltrera
通讯作者：
P. Porter;A. Gown;Steven G. Kramp;M. Coltrera
子宫内膜癌：孕激素受体和雌激素受体免疫组织化学定位的组织学相关性。
影响因子：
7.2
作者：
Segreti,EM;Novotny,DB;Soper,JT;Mutch,DG;Creasman,WT;McCarty,KS
通讯作者：
McCarty,KS
通过活检形态学预测“高风险”宫颈乳头瘤病毒感染。
影响因子：
3.5
作者：
Franquemont,DW;Ward,BE;Andersen,WA;Crum,CP
通讯作者：
Crum,CP