Virus vaccines: proteins prefer prolines.
Virus vaccines: proteins prefer prolines.
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DOI：
10.1016/j.chom.2021.02.002
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发表时间：
2021-03-10
影响因子：
30.3
通讯作者：
Moore JP
中科院分区：
文献类型：
--
作者：
Sanders RW;Moore JP
Most viral vaccines are based on inducing neutralizing antibodies (NAbs) against the virus envelope or spike glycoproteins. Many viral surface proteins exist as trimers that transition from a pre-fusion state when key NAb epitopes are exposed to a post-fusion form in which the potential for virus-cell fusion no longer exists. For optimal vaccine performance, these viral proteins are often engineered to enhance stability and presentation of these NAb epitopes. The method involves the structure-guided introduction of proline residues at key positions that maintain the trimer in the pre-fusion configuration. We review how this technique emerged during HIV-1 Env vaccine development and its subsequent wider application to other viral vaccines including SARS-CoV-2. The rapid development of spike protein-based COVID-19 vaccines was facilitated by various lessons learned over the past 20 years. Sanders and Moore review a method devised for HIV-1 vaccine development that was utilized in most COVID-19 vaccines: the stabilization of the spike protein by appropriately positioned proline amino acid substitutions.
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影响因子：
16.6
作者：
Krarup A;Truan D;Furmanova-Hollenstein P;Bogaert L;Bouchier P;Bisschop IJM;Widjojoatmodjo MN;Zahn R;Schuitemaker H;McLellan JS;Langedijk JPM
通讯作者：
Langedijk JPM
BNT162B2 mRNA COVID-19疫苗的安全性和功效。
DOI：
10.1056/nejmoa2034577
发表时间：
2020-12-31
期刊：
The New England journal of medicine
影响因子：
--
作者：
Polack FP;Thomas SJ;Kitchin N;Absalon J;Gurtman A;Lockhart S;Perez JL;Pérez Marc G;Moreira ED;Zerbini C;Bailey R;Swanson KA;Roychoudhury S;Koury K;Li P;Kalina WV;Cooper D;Frenck RW Jr;Hammitt LL;Türeci Ö;Nell H;Schaefer A;Ünal S;Tresnan DB;Mather S;Dormitzer PR;Şahin U;Jansen KU;Gruber WC;C4591001 Clinical Trial Group
通讯作者：
C4591001 Clinical Trial Group
影响因子：
5.9
作者：
Graham BS
通讯作者：
Graham BS
影响因子：
8.7
作者：
Sanders RW;Moore JP
通讯作者：
Moore JP
影响因子：
16.6
作者：
Battles, Michael B.;Mas, Vicente;McLellan, Jason S.
通讯作者：
McLellan, Jason S.